A Review on Oral Mucosal Drug Delivery System
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 1
Abstract
Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for prolonged time by mucoadhesive binding. The administration of drugs by the buccal route has several advantages over per oral administration such as QWICK ACTION, improved patient compliance particularly with pediatric & geriatric patient. It is the objective of this article to review the oral mucosal drug delivery by discussing briefly the structural feature of mucosa as drug delivery such as buccoadheshive film & tablet, medicated chew gum, fast dissolving tablet, film & capsule etc.
Authors and Affiliations
Rakesh Hooda, Mohit Tripathi, Kiran Kapoor
Keywords
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