Bismuth increases hydroxyl radical-scavenging activity of histamine H(2)-receptor antagonists.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 2
Abstract
The effects of histamine H(2)-receptor antagonists, alone or in a combination with bismuth, on ( )OH-provoked degradation of deoxyribose were studied. The histamine H(2)-receptor antagonists (cimetidine, ranitidine and roxatidine), themselves decreased the deoxyribose damage in Fenton-type systems. In combinations with bismuth, their inhibitory effect in Fenton system (Fe(III)/ascorbic acid + H(2)O(2) was stronger. Moreover, unlike F(III) and Cu(II), which in the presence of ascorbic acid + H(2)O(2) led to an increase in the ( )OH formation (deoxyribose damage), Bi(III) showed an opposite effect.The present results are interpreted in view of a better ( )OH scavenging activity of bismuth complexes of histamine H(2)-receptor antagonists as compared to that of the corresponding drugs. These findings might be one more explanation why bismuth salts, in combination with acid-reducing agents, are more effective anti-ulcer agents.
Authors and Affiliations
Margarita Kirkova, Albena Alexandrowa, Neli Yordanova
Keywords
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