Cytotoxic Effect of Methotrexate on Leishmaniadonovani Promastigotes
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 5
Abstract
Leishmania is auxotroph to folic acid,antifolates drug inhibit the synthesis and conversion of folate derivatives. In this study, cytotoxic effect of methotrexate was investigated on the procyclic promastigotes proliferation of L. donovani.The results showed a significant (p ≥ 0.05) difference in growth of treated groupsat high concentrations (1000, 500, 250, 125.5) μM after 24, 48 hrs., while at 72 hrs. significant difference was observed at all concentration. The IC50 values was measurable after 24, 48 and 72 hrs. and it was 174.238, 52.283 and 109.175 μM, respectively. The present study showed the cytotoxic effect of methotrexate on the proliferation of promastigotes of the visceral type of Leishmania.
Authors and Affiliations
Buraq Abdualameer Fingan, Hayder Zuhair Ali
Keywords
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- EP ID EP415700
- DOI 10.9790/3008-1305056569.
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