Incidence and Severity of Oral Mucositis in Patients of Head and Neck Cancers Receiving Definitive Radiotherapy with or without Chemotherapy: A Hospital Based Study
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Background: Head and neck cancers are among the ten most frequent cancers in the world and constitute 5% of all cancers worldwide. In developing countries like ours, cancer of the head and neck is among one of the commonest cancers. They account for one fourth of male and one-tenth of female cancers in India. Radiotherapy, with or without chemotherapy, is the mainstay of the treatment and oral mucositis is one of the major complaint and side-effect of the treatment in head and neck cancer patients. Material and Method: The present study comprised of total of 150 head & neck cancer patients receiving treatment at MD Oswal Cancer Hospital were enrolled in this study. Any Head and Neck Squamous cell carcinoma (AJCC Stage I-IV, M0 vide appendix no. I) patient receiving Radiation dose more than or equal to 56 gray, weekly concomitant chemoradiation in the form of Cis-platinum, Gemcitabine or Paclitaxel alternating with Gemcitabine were enrolled in this study. Results: Oral mucositis incidence was noted in 100% of the patients with chemo-radiation & was irrespective of chemotherapy used. The frequency of severe oral mucositis was 50% in radiotherapy alone group while 54.03% in chemoradiation group. Incidence of mucositis grade IV was more with cis-platinum being used as radio-sensitizer (62.9%) and was seen least in the gemcitabine arm (41.4%). Mean treatment time in all patients was almost same and around 59 days and it was not affected by the chemotherapy used. Conclusion: Severe oral mucositis (grade III and IV) was observed more in smokers, alcoholics, diabetics, opium addicts and patients having bad ODH. Mucositis resolves within 4-5 weeks period after the completion of treatment.
Authors and Affiliations
Pardeep Garg, Parveen Kaur, Rajesh Vashistha, Rupinder Singh, Ishu Sharma
Keywords
Related Articles
- EP ID EP544135
- DOI 10.21276/ijmrp.2017.3.2.043
- Views 57
- Downloads 0
Botulinum Toxin Type A Effects on the Treatment of Keloid Lesions: Comparison of Intralesional Two Different Doses
Background: Keloid is a lesion that creates from the excessive restoration of the scar and has beauty and functional complications for patient and changes their quality of life. Today, varieties of methods are used but b...
Continuous Epidural Analgesia in Labour Using 0.0625% Bupivacaine with 0.0002% Fentanyl and 0.125% Bupivacaine Alone: A Randomized Study
Aim: To evaluate the efficacy of Bupivacaine 0.0625% with Fentanyl 0.0002% and Bupivacaine 0.125%, in epidural analgesia for labour in relation to onset and duration of motor blockade, duration of analgesia, hemodynamic...
A Study of Psychiatric Comorbidity in Alcohol Dependent Patients in North-West Rajasthan
Background: Comorbidity indicated the presence of a individual clinical existence that has survive or may occur during the clinical course of a patient having the index disease. Though alcohol is one of the usually drugs...
Assessment of Nutritional Status and Change in Lean Body Weight in Head & Neck Cancer Patients Undergoing Radiotherapy
Introduction: The incidence of malnutrition among cancer patients has been estimated at between 40 and 80%. Malnutrition is a common problem in patients with Head and Neck Cancer. During treatment (Radiotherapy alone or...
Need of Anti-Glaucoma Drug Following Nd-YAG Laser Capsulotomy
Objective: Study to evaluate the need of an intra-ocular pressure (IOP) lowering topical agent after Neodymium-Yttrium Aluminum Garnet (Nd-YAG) laser capsulotomy. Methods: 120 patients with mild to moderate posterior cap...