PHYTOCHEMICAL COMPOSITION, BIOACTIVITY AND WOUND HEALING POTENTIAL OF EUPHORBIA HETEROPHYLLA (Euphorbiaceae) LEAF EXTRACT
Journal Title: International Journal of Pharmaceutical and Biological Research - Year 2010, Vol 1, Issue 2
Abstract
Villagers have traditionally used E.heterophylla parts to treat a variety of ailments. The objective of this study was to evaluate the phytoconstituents, bioactivity and wound healing potential of E.heterophylla leaf extracts in experimental Rattus novergicus.All experiments were conducted following standard procedures. The order of decreasing concentrations of the Phytochemical is alkaloids>cyanide >tannins>flavonoids> saponins. The order of decreasing cytotoxicity is aqueous extract (fresh)> ethanol extract (fresh)> ethanol extract (dry)> aqueous extract (dry). The extracts in the form of an ointment was used for evaluating the wound-healing potential in an excision wound model. The wound-healing property observed in E.heterophylla is attributed to the phytoconstituents and the faster process of wound-healing could be a function of either the individual or additive effects of the phytoconstituents.The ethanol extracts exhibited high percentage of wound closure. The prophylactic effect elicited by the extracts in terms of wound contraction and related biochemical parameter strongly support the healing and sealing characteristics of E.heterophylla leaf gel in rats following topical administration.
Authors and Affiliations
Omale James* , Emmanuel . T. Friday
Keywords
Related Articles
- EP ID EP145109
- DOI -
- Views 133
- Downloads 0
Development and Validation of HPTLC Method for the Simultaneous Estimation of Telmisartan and Ramipril in Combined Dosage Form
This paper describes developed and validated thin layer liquid chromatography (TLC) method for the simultaneous estimation of telmisartan and ramipril in a combined dosage form. Procedure does not require prior separatio...
Immunomodulatory activity of aqueous extract of Ocimum sanctum in rat
Background: Biochemical, haematological and Immunomodulatory effect of Ocimum sanctum in rat was studied. Objective: To evaluate the immunomodulatory effect of Ocimum sanctum in rat Methods: Aqueous extract of Ocimum san...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF NIFEDIPINE HYDROCHLORIDE USING MULTI-UNIT CHITOSAN TREATED ALGINATE
The main objective of the present work was to develop sustained release matrix tablets of water soluble Nifedipine hydrochloride using multi-unit chitosan treated alginate. Sustained release formulation is the drug deliv...
Protective effect of Indole 3 carbinol analogue and its Vanadium complex in hyperalgesia in STZ induced diabetic mice.
Neuropathic pain is generally considered to be one of the most common complications of diabetes affecting both type of diabetes equally. It is mostly characterized by pain which can occur spontaneously as a result of exp...
Evaluation of the Toxic Effects of Clozapine in Zebra fish (Danio rerio) embryos with the Fish Embryo Toxicity Test
Clozapine (an atypical antipsychotic drug) is indicated in treatment-refractory schizophrenia. Antipsychotics have been reported to have cardiotoxic effects in humans.The zebra fish (Danio rerio) is a tropical cyprinid u...