Protective Resistance by Human G6PD Enzyme Deficiency and Hemoglobin Variants Against Malaria and Natural Selection: Further Evidence from Review of New Studies
Journal Title: Edelweiss Applied Science and Technology - Year 2019, Vol 3, Issue 1
Abstract
Main objective of this article is to review and evaluate recent red cell variant studies for protection against malaria and natural selection. Malaria is a parasitic disease highly widespread in tropical and subtropical regions of the world. It is also one of the leading causes of death worldwide and genes involved in malaria resistance are the most important for natural selection in human populations. Multiple red cell variants, which evolved probably to counter the lethal effects of malaria and confer protection against malaria through different mechanisms, show high frequencies in malaria endemic vulnerable populations. Different natural protective/resistance mechanisms including hampering of parasite growth, invasion related immunological responses or rapidly elimination of malaria parasite from the infected erythrocytes of host have briefly been discussed, evaluated and reviewed. Conclusions drawn have been projected here. High frequency of inherited hemoglobin disorders including thalassemias and red cell G6PD enzyme deficiency, which seemed to evolve simultaneously in relation to malaria and high mortality caused by Plasmodium falciparum malaria in different vulnerable populations of tropical and subtropical parts of world, confirm that the natural selection is certainly operating against malaria in one way or another; and human population genetics have distinctly played a significant role in the co-evolution of host and malaria. The inverse relationship between sickle cell trait and G6PD deficiency and vice versa, revealed by allele frequencies distribution shown in our previous studies, is a testimony of disequilibrium, as sickle cell allele being replaced by G6PD deficiency allele in populations of central India. Positive natural selection plays a definite role against malaria for maintaining balance in high frequency endemic populations.
Authors and Affiliations
Balgir RS
Keywords
Related Articles
- EP ID EP678503
- DOI https://doi.org/10.33805/2576-8484.167
- Views 153
- Downloads 0
Communicating to Drive Sustainability-A Worked Example with Wind Power
We demonstrate the knowledge-development power of the emerging science of Mind Genomics, doing so by a study of appeals to fund a wind-power project in Texas. The paper focuses on the method, analyses, results, and appli...
Asymptomatic Hemangioma of the Duodenum
Hemangiomas of the small bowel are exceedingly rare benign tumors. When diagnosed they are found in the setting of an acute gastrointestinal bleeding, but can also be involved in intussusception, obstruction, and cause p...
An Assessment of Parents-Adolescents Communication on Sexual and Reproductive Health Matters between Evelyn Hone College Lecturers and their Adolescent Children, Lusaka, Zambia
Background: One of the neglected issues in our society today, is effective communication between parents and adolescents on matters of Sex and Reproductive Health. This problem has saliently exposed the adolescents to th...
Developing Process of Regular Labor Contraction
Aims: To clarify the developing mechanism of uterine contraction curve in the birth process. Methods: Uterine contraction curve, which was constant in old and new studies and recording methods, and it is similar to the e...
Corrosion Inhibition Potential of Ethanol Extract of Bryophyllum pinnatum Leaves for Zinc in Acidic Medium
The inhibitive and adsorption properties of ethanol extract of Bryophyllum pinnatum leaves were studied using weight loss, potentiodynamic polarization, Scanning Electron Microscopy (SEM) and Fourier transformed infra-re...