Radiation-induced Testicular Injury and Its Amelioration by Telfairia occidentalis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 12
Abstract
Aims: The radioprotective effect of Telfairia occidentalis aqueous extract (TOE) against gamma irradiation induced oxidative damage and altered sperm parameters in rats. Study Design: Randomized controlled experiment Place and Duration of Study: Experimental Animal Unit and Department of Anatomy, University of Ibadan between January and April, 2012. Methodology: Male Wistar strain rats were divided into six groups and pretreated with TOE (400, 800 and 1600 mg/kg of b.wt.) and vitamin E (VE) 50 mg/kg of b.wt prior to whole body gamma irradiation exposure of 2Gy. Sections of the testes were taken for the assessments of biochemical markers of oxidative stress: Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) and histopathological variations. Results: Exposure of animals to 2Gy gamma radiation resulted in decreased sperm characteristics and increased sperm morphological abnormalities; significant elevation in lipid peroxidation (LPO) and hydrogen peroxides, and decreased activities of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GSH-Px) and levels of reduced glutathione (GSH) in testes; distorted architecture of seminiferous tubules from day 1 to 30 post-irradiation. The rats pretreated with TOE showed normal sperm parameters, normal testicular histo-architecture and normal antioxidant enzymatic activities. Conclusion: Aqueous extract of Telfairia occidentalis has radioprotective activities.
Authors and Affiliations
S. A. Adejuwon, J. O. Omirinde, A. P. Ebokaiwe, O. O. Aina, A. Adenipekun, E. O. Farombi
Keywords
Related Articles
- EP ID EP348945
- DOI 10.9734/BJMMR/2014/8235
- Views 78
- Downloads 0
Ultrastructure of Thyroid and Parathyroid Bodies in Case of Hypocalcemia and Hypercalcemia
Aims: To analyze ultrastructural transformations of parafollicular cells of thyroid body and main cells of Parathyroid body in case of experimental blood hypocalcemia and hypercalcemia. Place and Duration of Study: Tashk...
Glucose-lowering Potential of Cocoa Powder Intake - An Avenue for Positive Management of Diabetes Mellitus
Diabetes mellitus (DM) is a public health problem which is increasing all over the world and various contributions to its prevention and management is crucial. Cocoa powder as a food ingredient has been discovered to hav...
Neuroprotective Mechanism of Ethanolic Extract of Irvingia gabonensis Stem Bark against Cadmium-induced Neurotoxicity in Rats
Objective: To explore the neuroprotective effect of Irvingia gabonensis (IG) against cadmium-induced oxidative damage in rats brain. Place and Duration of Study: Department of Chemical sciences, (Biochemistry laboratory...
Ascitic Antigen CA125: Study of Dissociaton Forms and its Final - Stem Structure
Aim: Study of dissociation forms of the ascites antigen СА125 and its stem structure – the final form of its dissociation. Study Design: Resarch paper. Place and Duration оf Study: Department of biochemistry, N.I. Pirogo...
Histomorphological and Biochemical Effects of Ethanolic Extract of Monodora myristica Seed (African Nutmeg) on Some Liver Function Parameters Using Albino Wistar Rats
Aim: This study was carried out to investigate the effects of Monodora myristica on the physiological status of the liver using albino Wistar rats as a model. Study Design: This research was conducted at the Department o...