Role of CT Perfusion in Differentiation between High and Low Grade Glioma
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 11
Abstract
Gliomas, the most common primary brain neoplasms in adults, are very heterogeneous tumors. High-grade gliomas can be highly invasive and extremely vascular tumors. (1) Glioma grading is currently based on the histopathologic assessment of the tumor, which is achieved by stereotactic brain biopsy or cytoreductive surgery; and there are inherent limitations with these techniques and their interpretation. (1) Therapeutic approaches, response to therapy, and prognosis depend on accurate grading, and thus finding the part of the tumor with the highest grade to be biopsied is critical. (1) The aim of this study was to evaluate role of CT perfusion in differentiation between low grade and high grade glioma Methods: This is study was conducted on 32 patients from 2012 to 2013.All patients were examined by CT perfusion The patients were subjected to surgery and pathological analysis, then correlation between CT results and pathological analysis was done. Results: In our study mean CBV for high and low grade glioma was 11.5ml/100gm and 0.36ml/100gm respectively with statistically significant value between two groups (P value= .037), the cut of value in was 2.9 ml /100gm with sensitivity 91% and specificity 100%.The CBF for high grade and low grade glioma was 168.6 ml/100gm/min and 13.3 ml/100gm/min respectively with statistically significant difference between two groups (P=.023). Cut of value was 38.8ml/100gm/min for CBF with sensitivity 91% and specificity 100% and for men PS in low and high grade glioma was 0.25 and 13.9 respectively with statistically significant difference (P value =.005) , the cut of value was 2 ml/100gm/min with sensitivity 91% and specificity 100% , for mean MTT for high and low grade glioma 4.6and 7.08 respectively with no statistically significant difference (P value =0.137) . Conclusion: CT perfusion is a valuable method in differentiation between low and high grade glioma, it has the advantage of wider availability, faster scan time and lower cost compared to MR perfusion
Authors and Affiliations
Tarek M. Rashad Saleh
Keywords
Related Articles
- EP ID EP212774
- DOI -
- Views 53
- Downloads 0
Mental Morbidity among Medical Students in India
Aims: The current study compares the rate and pattern of mental morbidity in medical students of first semester and final semester and to evaluate its association with socio-demographic and other variables. Methods and M...
Exercise Therapy with Evidence on Post Traumatic Stiffness (Knee)
This case study where 14 year old subject following post epiphyseal fracture of tibia treated conservatively. Aims and Objectives: Aims and objective of this presentation was to analyse impact of various means of exercis...
Cataract Surgery by Phacoemulsification – Surgical and Visual Outcome with Foldable and Non-Foldable Lenses
This prospective comparative study included 300 matched patients of different grades of senile cataract. All of them willfully underwent phacoemulsification at the hands of a single experienced surgeon, performing with a...
A study of knowledge, attitude and practice of corticosteroid use among prescribers in a tertiary care centre in Maharashtra
Introduction: Corticosteroids therapy is always associated with multiple drug interactions, adverse effects and super infections. Over the years, corticosteroids are apparently being abused by doctors and patients alike....
Fungal Keratitis – Epidemiology and Treatment Outcome - In North Costal Andhra Pradesh
Purpose: To review the distribution, current trends, and response patterns for treatment of fungal keratitis isolates in costal districts over the last 2 years Methods Design: Retrospective, observational, case series. P...