1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
Journal Title: UNKNOWN - Year 2018, Vol 8, Issue 3
Abstract
1-Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and microorganisms. It has been widely used to investigate the biological roles of cytochrome P450 enzymes, their participation in the metabolism of both endobiotics and xenobiotics, and their contributions to the metabolism-dependent toxicity of drugs and chemicals. This review is a comprehensive evaluation of the chemistry, discovery, and use of 1-aminobenzotriazole in these contexts from its introduction in 1981 to the present.
Authors and Affiliations
Paul R Ortiz de Montellano
Keywords
Related Articles
- EP ID EP672548
- DOI -
- Views 82
- Downloads 0
Synthesis and Antioxidant Activity of Mixed Ligand Complex of Quercetin and Aspartic Acid with Cobalt(II)
Mixed ligand complexes are widely used in the field of pharmaceutical science due to their curing nature to various diseases. The present study was aimed to synthesize and explore the antioxi...
EGFR Tyrosine Kinase Targeted In Silico Design and Synthesis of Novel Quinazoline Derivatives
Quinazolines are medicinally important as anti-convulsant, anti-cancer, anti-microbial, and anti-tubercular properties etc. They target epidermal growth factor receptors on tumor cells. This work is aimed to synthesize a...
Synthesis and Characterization of New Coumarin Substituted Chromone (8-Methyl-4-phenyl-2H,10H-pyrano[2,3-f] chromene-2,10-dione) Using Benzyl Acetoacetate and Studied their Fluorescence Properties
In the present review developed a new method for synthesis coumarin substituted chromone, as they are an important building block in organic chemistry. Also, they are valuable synthetic intermediates in the preparation o...
Anti-Metastatic Drug Developments: Work Out towards New Direction
Neoplasm metastasis is a multiple-step and multi-level feature that is resistance to current norm of anticancer drugs. More seriously, current anticancer drugs are commonly derived from in vitro tumor cell line data or a...
An Alternative Approach to Computational Peptidology Based on Conceptual DFT and Empirical Bioactivity Scores
This work presents the results of a study of the global and local chemical reactivity of the antineoplastic Elisidepsin and Plitidepsin marine drugs based on the calculation of descriptors coming from Conceptual DFT for...