4-(3,4-Dichlorophenyl)-6-(Furan-2-yl)Pyrimidine-2-Thiol as Building Block in Heterocyclic Synthesis
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2013, Vol 5, Issue 2
Abstract
Pyrimidine-2-thiol (1) has been synthesized via one-pot, three component synthesis. Its behavior towards nitrogen nucleophiles like hydrazine hydrate, ethylamine, piperidine, and 2-aminobenzoic acid has been studied. A speculation to explain the activities of the thioamide-iminothiol equilibrium based on their thermodynamic and kinetic control under the experimental conditions were investigated. The hydrazinopyrimidine 2 and aminocarbamoyl derivative 8 were used as key starting materials for synthesis of some interesting nitrogen bridgehead compounds 10-13, hydrazones 14-16, and some mixed and non-mixed heterocyclic systems 17-19 respectively.
Authors and Affiliations
M. A. EL-Hashash, Yaser Abdel-moemen El-badry, J. M. Morsy
Keywords
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- EP ID EP652573
- DOI 10.24297/jac.v5i2.2656
- Views 153
- Downloads 0
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