4-chloro-6-methoxy-2-styryl quinoline, its synthesis and antibacterial activity
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2016, Vol 4, Issue 1
Abstract
P-anisidine on treatment with ethyl aceto acetate in refluxing ethanol for 4hrs gave Ethyl-3-[4-methoxyphenyl) imino] butanol which is on thermal cyclization in hot propylene glycol at 1000c gave 4-hydroxy-6-methoxy-2-methyl quinoline. The latter on heating with POCl3 gave 4-chloro-6-methox-2-methyl quinoline which on treatment with benzaldehyde gave corresponding 4-chloro-6-methoxy-2-styryl quinoline. The product have been characterized based on the spectral data and have been evaluated for its antibacterial activity.
Authors and Affiliations
B. Deepthi
Keywords
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