A BRIEF INTRODUCTION TO METHODS OF PREPARATION, APPLICATIONS AND CHARACTERIZATION OF NANOEMULSION DRUG DELIVERY SYSTEMS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
Nanoemulsions have attracted great attention in delivery of therapeutically active agents since approximately 40% of new chemical entities are hydrophobic in nature and the delivery of these poorly water soluble drugs is a challenge for delivery of drugs. The emulsions and Nanoemulsions differ mainly in the size and shape of the particles dispersed in the continuous phase. The particle size in nanoemulsions is (10-200nm) and those of conventional emulsions are (1-20µm). Nanoemulsions are prepared by high energy emulsification methods like micro fluidic and ultrasonic methods, these methods rupture large micro droplets into nano scale droplets. Oil in water (O/W) and water in oil (W/O) nanoemulsions were prepared by aqueous phase titration method. Nano emulsions can be evaluated for their morphology, droplet size, viscosity, PH, optical clarity, zeta potential, conductivity, transmission electron microscopy and polydispersity. Nanoemulsions find application in controlled drug delivery, targeted drug delivery, nutraceuticals, food products, transdermal and colloidal drug delivery. This article includes preparation, characterization, evaluation and application of nanoemulsions.
Authors and Affiliations
Haritha, Syed Peer Basha, Koteswara Rao P, Chakravarthi Vedantham
Keywords
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