A BRIEF REVIEW ON PROCESS ANALYTICAL TECHNOLOGY
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 7
Abstract
Process analytical technology (PAT) has been defined as a mechanism to design, analyze and control pharmaceutical manufacturing processes through measurement of critical process parameters which affect critical quality attributes. PAT checks the quality of raw material attributes both off-line, on-line & in-line.The main principle of PAT is the use of different technologies and tools to build quality into the products. Effective implementation of PAT comprise of science-based understanding of the physical, chemical and mechanical properties of all elements of the proposed drug product. The application of early PAT devices, increase safety & process efficiency by acting on data in real time and by eliminating sampling. PAT applies it gives brief knowledge of processes, leading to increased robustness and greater processing opportunities. chemical reactions and process monitoring such as drying, distillations, crystallizations, hydrogenations, and others provided by Modern developments in analytical technologies. while implementing PAT into their new and pre-existing manufacturing processes many pharmaceutical companies face many challenges and problems. In this paper, we will start with brief PAT concepts, Introduction, How PAT works, Importance of PAT tools, PAT implementation steps and a review of their application in the wider pharmaceutical industry.
Authors and Affiliations
Pallavi Gaikwad
Keywords
Related Articles
- EP ID EP671098
- DOI -
- Views 203
- Downloads 0
OCULAR SURFACE AND GLAUCOMA MEDICAL THERAPY
PURPOSE: To compare the impact on the ocular surface of glaucomatous patients under monotherapy by latanoprost, tafluprost, bimatoprost and bimatoprost/timolol 0.50% fixed combination. PATIENTS AND METHODS: This is a sin...
A STUDY OF MEDICATION USE DURING PREGNANCY IN SHARJAH-UNITED ARAB EMIRATES.
Aims: This investigation was carried out as a pilot study to explore the use of medications during pregnancy in Sharjah-UAE. Methods: An anonymous pre-piloted questionnaire was distributed to 250 pregnant women attending...
A STUDY TO ASSESS THE RESILIENCE AMONG THE FAMILY MEMBERS OF PATIENT WITH ALCOHOL DEPENDENCE
• Handling a family member (men) with alcohol dependence is a challenging task for family members. Regular consumption of alcohol leads to domestic violence and other family problems. Alcohol Dependence is a group of phy...
COMPARISON OF BODY MASS INDEX AND BLOOD PRESSURE IN COMMERCIAL MOTOR DRIVERS IN PORT HARCOURT, NIGERIA.
This study aimed at investigating the relationship between the body mass index (BMI) and blood pressure (BP) of commercial motor drivers (CMDs) in Port Harcourt, Nigeria. Five hundred and seventeen (517) consenting male...
PHARYNGEAL HEMORRHAGE: A CATASTROPHIC POST-OPERATIVE EVENT
Hematoma of pharyngeal muscles is an unknown and potentially fatal cause of airway obstruction. We report a case of a 71 year old woman who received a long lasting combined, carotid + CABG, operation and developed severe...