A brief review on recent advances of extended release technology employed to design the oral dosage forms
Journal Title: International Journal of Medical and Biomedical Studies - Year 2017, Vol 1, Issue 6
Abstract
The benefits offered by modified release systems include reduced dosing frequency with improved patient compliance, better and more uniform clinical effects with lower incidence of side effects and possible enhanced bioavailability. Characteristics of a modified release system as stated by USP is “The drug release characteristics of time, course and / or location are chosen to accomplish therapeutic or convenience objectives not offered by conventional dosage forms” [1]. This includes technologies that modify the site of drug delivery. Extended release dosage forms extend the life of a drug so that dosage regiment shifts from 3 times a day dosing just once or twice a day. The successful formulation of a modified release device requires a comprehensive understanding of the mechanism of drug release from the macroscopic effects of size, shape and structure through to chemistry and molecular interaction. Multiparticulate dosage forms shown to be less prone to food effects than monolithic and is often the preferred formulation for extended and / or delayed release. Extended release drug formulation is conventionally produced as compressed tablets by hydrogel tablet technology. To produce these extended release tablet dosage forms, active ingredient is conventionally compounded with cellulose ethers like methylcellulose, ethyl cellulose or hydroxyl propyl methylcellulose with or without excipients and the resulting mixture is pressed into tablets.
Authors and Affiliations
Anil K. Gupta, Dr. B C Nandy
Keywords
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- EP ID EP416443
- DOI 10.32553/ijmbs.v1i6.6
- Views 126
- Downloads 0
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