A Case of Glioblastoma Multiforme in a Known Case of Breast Carcinoma
Journal Title: GCSMC Journal of Medical Sciences - Year 2017, Vol 6, Issue 2
Abstract
Glioblastoma multiforme, also known as grade IV astrocytoma, is a fast growing, aggressive type of central nervous system tumor that forms on the supportive tissue of brain. These tumors contain various cell types, hence the name multiforme, the most common being astrocytes. The literature reports many cases of primary breast carcinoma having coexisting glioblastoma multiforme either at the time of diagnosis of breast carcinoma or later. This association may not be due to chance but rather to genetic changes in hormone status and in particular to sex hormones. Another important point of view is represented by the chemotherapy treatment of breast cancer, which could have a carcinogenic effect and explain the growth of glioblastoma. This consideration, in our opinion, is important, because more effort should be made to understand the pathogenesis of glioblastoma multiforme and to improve the therapeutic approaches.
Authors and Affiliations
Seva Makwana, Drashti Thakkar, Rajul Shah, Preeti Jhaveri, Cherry Shah, Nailesh Shah
Keywords
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