A clinical study of hepatic dysfunction in severe birth asphyxia neonates
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 6
Abstract
Background: The effect of asphyxia on the liver and the hepatic functions of the neonate is unexplored. This study was done to see the status of SGOT, SGPT, Alkaline phosphatase and Serum bilirubin in asphyxiated babies and to know the correlation existing between hepatic dysfunction and severity of perinatal asphyxia. Objectives: This study was undertaken to assess the liver function in healthy newborns and in severe birth asphyxiated babies and compare with the controls. It was also done to collect the information about severity of liver damage and their prognostic value. Methods: A prospective cohort study was done in Krishna Institute of Medical Sciences, Karad involving 30 severely birth asphyxiated neonates and 11 full term normal neonates were taken as controls. Liver enzymes that is SGOT, SGPT, Alkaline phosphatase, and Serum Bilirubin were estimated in serum of neonates included in this study. Results: SGOT, SGPT, Alkaline Phosphatase were significantly higher in neonates of study group as compared to neonates of control group. Among the asphyxiated newborns SGOT, SGPT, Alkaline Phosphatase were significantly raised in neonates who succumbed to asphyxia than those who survived. Levels of Serum Bilirubin were also raised in expired than who survived. Interpretation and conclusion: Severe birth asphyxia causes liver dysfunction. Approximately 76% of severely asphyxiated neonates suffered from deranged hepatic function. Enzyme derangement is significantly more in those neonates who succumbed to asphyxia than those who survived.
Authors and Affiliations
Dr. SY Ingale, Dr. Aieshwarya Pradhan
Keywords
Related Articles
- EP ID EP586422
- DOI -
- Views 141
- Downloads 0
Incidence of acute kidney injury and its associated factors among snake bite patients in rural area of Salem district
Background: In India Agriculture being one of the major occupations, snake bite is a familiar occupational hazard of farmers, plantation workers and others, resulting in tens of thousands of deaths each year and innumera...
Comparison of MRI as imaging of carcinoma cervix
The study was planned to compare the CT & MRI findings in the cervical carcinoma. It will be helpful for the detection of earliest lesion, parametrial assessment, early vaginal and uterine invasion, urinary bladder and r...
Rejuvenating aesthetics by mixing different ceramic stains
The replacement of natural teeth, especially with single- tooth porcelain bonded to metal restorations of truly satisfactory esthetics, represents a challenge. Insertion of porcelain bonded to metal restoration that not...
Maternal obesity and its impact on pregnancy outcome
To assess the effects of obesity on pregnancy and to compare it with non-obese patients. Obesity is a worldwide epidemic that will reach over one billion people by 2030. Women who are overweight or obese during pregnancy...
Electroconvulsive therapy in severe depression: Effect on cognition
Introduction: Depression is the leading global cause of disability and approximately, 350 million people suffer from depression worldwide. Despite the availability of numerous psychopharmacological treatments, evidence i...