A Co-relative Study of ADA and CYFRA 21-1 in Serum and Pleural Effusion Secondary to Tuberculosis and Cancer
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 8
Abstract
Abstract: Lung cancer and Pulmonary Tuberculosis are two major public health problems associated with significant morbidity and mortality in India. Wrong diagnosis of lung cancer cases as pulmonary tuberculosis delays the onset of anti-cancer chemotherapy and initiation of DOTS thus increases complication in malignancy patients. In this context easy, cost effective diagnostic tool at primary level must be the priority and need of hour. This study was done to evaluate any significance of ADA, CYFRA 21-1in serum and pleural effusion secondary to tuberculosis and lung cancer.Case control study was carried out on 100 cases of tuberculous effusion, 50 cases of malignant effusion and 100 age and gender matched apparently healthy controls. Correlation between ADA and CYFRA 21-1 was evaluated to find any significance between three groups. Blood and pleural fluid samples were collected and analyzed by using Erba Mannheim Chem 5 plus V2 semi autoanalyzer and LISA SCANII Elisa reader. Statistical analysis was done by using ANOVA and student’s‘t’ test. P value <0.05 was considered significant. ADA levels in serum and pleural fluid was significantly higher in pulmonary TB group than lung cancer group(‘p’ <0.001) and both are higher than control group(‘p’<0.001).CYFRA 21-1 in serum and pleural fluid was significantly higher in lung cancer group than TB group(‘p’ < 0.001) but both were higher than control group(‘p’<0.001).The results suggests early quantization of these parameters can differentiate pulmonary tuberculosis from lung cancer and thus can decrease the mortality rate of lung cancer cases though more extensive study with increased sample size may provide more insights.
Authors and Affiliations
Sumeru Samanta, Ashish Sharma, Biswajit Das, Ayaz K Mallick, Amit Kumar
Keywords
Related Articles
- EP ID EP372444
- DOI -
- Views 65
- Downloads 0
The Ameliorative Effect of Vitamin a and Stem Enhancer on Cytological Changes and Apoptosis Inducing-Activity in BPA-Treated Murine Model
Bisphenol A is a plasticizer used as monomer of epoxy resins and polycarbonate plastics which found in many different applications such as adhesives and paper coatings, food related containers and water bottles; what mak...
Blood Group Distribution in a Study Population and their Associated Rhesus Factor (Uganda)
Whole blood transfusions have continuously been done in medical hospitals as the major line of emergency recovery on the African continent as a result of limited infrastructure despite of the fact that the general blood...
Prevalance of Hypertension among Fishermen Population in Tamilnadu
Hypertension is one of the major public health issues in worldwide. The objective of this study was to find out the prevalence of hypertension and its associated risk factors in fishermen population of Tamil Nadu, India....
Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV in Patients of Chronic Liver Disease: Study from a Tertiary Care Centre in North-West India
Abstract: Worldwide more than 130 million people are chronically infected by hepatitis C virus (HCV) infection. Hepatitis B virus (HBV) and hepatitis (HCV) C virus are endemic in India and have an etiological role in acu...
Study of Bone marrow aspiration and biopsies in Pancytopenia – A study on 48 patients
Abstract: Pancytopenia is a relatively common entity. However, it has received inadequate attention in the Indian subcontinent. A study of pancytopenia using easily available diagnostic techniques is therefore relevant....