A Comparative Study between Intrathecal Clonidine and Buprenorphine with Intrathecal Bupivacaine for Lower Abdominal Surgeries
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 1
Abstract
Purpose: Subarachnoid (spinal) block is a safe and effective alternative to general anesthesia when the surgical site is located on the lower extremities, perineum (eg, surgery on the genitalia or anus), or lower body wall (eg, inguinal herniorrhaphy). In no other way, can an anaesthesiologist obtain so much of an effect for the introduction of a small quantity of the drug. Likewise a properly chosen adjuvant to local anaesthetic agent produces the best way to achieve a good quality regional block. Aim of Study: To compare the effect of intrathecal Clonidine 75 micrograms (µg) and Buprenorphine 150 µg with 2.5ml (12.5mg) of intrathecal 0.5% hyperbaric Bupivacaine. With regards to: 1) Sensory characteristics, 2) Motor characteristics, 3) Hemodynamic stability and 4) Side effects. Methodology: A prospective randomized experimental study were performed on 50 patients posted for lower abdominal surgery belonging to ASA I and aged between1860 years after obtaining an informed consent and ethical clearance. Result: Addition of 150 µg Buprenorphine significantly enhances the onset of sensory block (90±15 secs) and motor block (150±15 secs) than compared to Clonidine onset of sensory block(150±20 secs) and motor block(210±20 secs) (p<0.05). Hemodynamic was well maintained with buprenorphine group. And addition of Buprenorphine 150µg to intrathecal Bupivacaine(0.5%) produces prolonged analgesia (526±96) than compared to the Clonidine group of 362±36mins (p<0.05) with no serious adverse effect noted perioperatively in either groups. Conclusion: The addition of Buprenorphine to intrathecal Bupivacaine (0.5%) prolongs the duration of post operative analgesia than compare to clonidine. Buprenorphine has faster onset of sensory and motor blockade than compare to clonidine.
Authors and Affiliations
Yoganarasimha N.
Keywords
Related Articles
- EP ID EP462928
- DOI 10.21088/ijaa.2349.8471.4117.17
- Views 116
- Downloads 0
A Comparative Study between Oral Pregabalin 150mg and Gabapentin 300mg for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy
This study designed to test the hypothesis that the preoperative use of pregabalin will reduce th consumption of analgesics after laparoscopic cholecystectomy and to compare its efficacy and side effects with that of gab...
A Randomised Prospective Double Blinded Study of Intrathecal Levobupivacaine with Fentanyl Verses Clonidine for Infraumblical Surgeries
Background and aims: Subarachnoid block can be performed with many local anaesthetic agents. Besides hyperbaric bupivacaine even isobaric levobupivacaine and ropivacaine can also be used with minimal cardiotoxicity. Adju...
A Comparison Between Airtraq Optical Laryngoscope and Conventional Macintosh Laryngoscope for Intubation in Adult Surgical Patients: A Prospective Randomized Controlled Study
Tracheal intubation using a laryngoscope is considered as a gold standard 1 of airway management during administration of general anesthesia and also in critical care settings because of its several advantages including...
Comparison of Ropivacaine with Clonodine Versus Ropivacaine alone in Supraclavicular Block: A Randomised Study
Introduction: Ropivacaine is a new local anesthetic agent with minimal cardiovascular toxicity. Various adjuvant have been tried with local anesthetics to prolong post operative analgesia, clonidine is one such drug. The...
Comparative Evaluation of Intraocular Pressure after Various Intravenous Inducing Agents
Background: General anaesthesia has effects on various systems including intraocular pressure (IOP). Anaesthetic drugs also lead to changes in IOP. Though rare, IOP measurement is important as acute glaucoma is a major c...