A Comparative Study between Two Different Intracavitary High Dose Rate Brachytherapy Schedules with Concurrent External Beam Radiotherapy in Cervical Cancer Stage – II
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 11
Abstract
Background: High Dose Rate (HDR) intracavitary Brachytherapy (ICBT) is essential for successful management of locally advanced cervical cancer. The quest is to interdigitate it with External Beam Radiotherapy (EBRT) to complete the treatment within 8 weeks and with fewer toxicities. Objective: To compare and analyze results of Two HDR ICBT schedules of 6 Gray (Gy)/#(fractions) for 4 fractions (in Arm A), and 7.5 Gy/# for 3 fractions (in Arm B) given in concurrent form with EBRT to whole pelvis and weekly chemotherapy. Materials and Methods: This study is a prospective randomized control trial performed in a regional cancer center located in Bikaner, Rajasthan from march 2017 to may 2018. Total of 42 cases of histologically proven squamous cell cancer of cervix satisfying our inclusion criteria were randomized into two arms. After completion of 20 Gy through EBRT cases in Arm A received 6 Gy / # for 4 # of HDR ICBT, while cases in Arm B received 7.5 Gy / # for 3# on every Saturday. Results: The Median follow up period of study was 19 months. There is no significant difference in local control and late toxicities in both arms. Conclusion: In our experience 7.5 Gy /# for 3# and 6 Gy /# for 4 # when given with EBRT produces equal results and are equally tolerated by patients, though these regimes required to be compared with conventional regimes (HDR ICBT followed by EBRT)
Authors and Affiliations
Narendra Kumar Gupta
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