A Comparative Study of Clinical Efficacy of Timolol0.5% AndDorzolamide 2% Eye Drops in Primary openAngle Glaucoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Introduction: Glaucoma is recognized as a major cause of ocular morbidity. About 60.5 million people are affected by glaucoma Worldwide. Raised intra-ocular pressure (IOP) remains a strong risk factor and it has been shown that the higher the IOP at presentation, the greater the risk of developing POAG (primary open angle glaucoma)Medical treatment is the first line of management and includes the use of several classes of topical agents. Methods: A prospective, randomized, comparative-efficacy study included sixty patients of primary open angle glaucoma. Efficacy was assessed as the change in IOP from baseline, visual acuity and visual field analysis for every 2 weeks for six months. Safety was assessed with adverse event rates, Ocular irritation, Ocular pain, Blurring of vision. Results: The mean reduction of IOP for timolol group in both the eyes was15.55 mmHg and in the dorazolamide group it was13.47 mmHg. Visual acuity and the field of vision were same as recorded at baseline visit.Patients in the Dorzolamide group had a higher incidence of adverse events compared to the timolol group. Conclusion: There was no significant difference in the reduction of IOP in either of the eyes or on an average IOP with either drugs, both can be used to reduce the IOP.Both the drugs were well tolerated with 20% more of the adverse effects seen with Dorzolamide.
Authors and Affiliations
Dr. Kasu Akshara, Dr. Khan I, Dr. V. Naga Jyothi, Dr. Praveena Gungam
Keywords
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- EP ID EP257853
- DOI 10.9790/0853-1609111317
- Views 79
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