A Comparative Study of Coagulation Profile in Pre-Eclamptic and Normotensive Pregnant Females
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Hypertensive disorders complicating pregnancy are common and form one of the deadly triad along with hemorrhage and infection that results in maternal and perinatal morbidity and mortality. In developing countries with uncared pregnancy, this entity on many occasions remains undetected till major complications supervene. The abnormalities of coagulation parameters like prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen levels are usually observed in severe preeclampsia and Eclampsia.Our study aimed to analyse the utility of coagulation tests (prothrombin time, activated partial thromboplastin time and plasma fibrinogen and FDP levels) in pre-eclampsia so as to prevent fatal complications and early detection, careful monitoring and appropriate management of gestational hypertension to reduce the morbidity and mortality of both mother and child. The present study is a prospective case control study carried out in Department of Pathology and Department of obstetrics and gynecology in J. K. Hospital Bhopal associated with L.N.Medical College over a period from May 2016 to October 2017. Total 140 subjects, 70 control and 70 cases were enrolled in the study. In preeclampsia group, the mean prothrombin time and mean activated partial thromboplastin time was found to increase gradually with progression of disease in present study. In present study the mean fibrinogen level found to be significantly decreased in cases than in controls. There was gradual decrease of fibrinogen level with progression of disease from mild pre eclampsia to severe pre-eclampsia and was statistically significant. The mean fibrin degradation products (FDP) levels in the present study were significantly increased as compared controls. Low fibrinogen levels and increase in fibrin split products (D-Dimer) with increasing severity of preeclampsia suggest these products may serve as a marker of coagulopathy and the aggressive management towards early delivery may result in decreasing morbidity and mortality.
Authors and Affiliations
Pratibha Meena, Amit Gupta, Shailendra Meena, Rupinder Kalra
Keywords
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- EP ID EP369938
- DOI 10.9790/0853-1703154958.
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