A comparative study of efficacy and safety of Olopatadine and Levocetirizine in seasonal Allergic Rhinitis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Abstract: Allergic rhinitis (AR) is one of the common prevalent diseases representing approximately 20% of the general population. Allergic rhinitis (AR) has a relevant impact on society because of its high prevalence, association with an impaired quality of life and the presence of co-morbidities such as atopy and asthma. The aim is to compare the therapeutic efficacy of Levocetirizine and Olopatadine in the treatment of Seasonal Allergic Rhinitis and to compare their safety in terms of incidence of adverse effects. The study was conducted on 90 patients of seasonal allergic rhinitis attending the Department of ENT, Prathima Institute of Medical Sciences, Nagunur, and Karimnagar. In this study 90 subjects suffering from Seasonal Allergic Rhinitis were included. At the first visit, after clinical evaluation and laboratory investigations (DC Eosinophil, Absolute Eosinophil Count, IgE levels), Olopatadine group: n=45 patients were in this group received Olapatadine 10 mg once daily for 2 weeks.Levocetirizine group:n=45 patients were in this group received Levocetirizine 10 mg once daily for 2 weeks. After 2 weeks, all laboratory investigations were repeated and clinical improvement was assessed in terms of change in TNSS scoring and laboratory parameters. TNSS was considered as primary outcome measure. Among 90 patients, 48 patients (53.33%) were female and 42 patients (46.66%) were male. There was a mean decrease of 294.77 in Absolute Eosinophil Count (AEC) in Olopatadine group in comparison to 176.56 in Levocetirizine group. Serum IgE levels (UI/ml)were measured before and after 2 weeks and the results in Olopatadine group there was a mean reduction of 92.04 (UI/ml)in IgE in comparison to 43.28 (UI/ml)in Levocetirizine group. The individual changes in both the groups were statistically significant (<0.001). Total Nasal Symptom Score [TNSS] was assessed. There was a mean decrease of 3.39 in TNSS in Olopatadine group whereas it was 2.92 in Levocetirizine group. Levocetirizine and Olopatadine have been found effective in symptomatic treatment of allergic rhinitis. However Olopatadine was found to have edge over levocetirizine because Olopatadine additionally suppresses LTs and TXA2 release and PAF formation by reducing arachidonic acid release from membrane phospholipids, probably through interference with phospholipase A2 (PLA2). Both drugs have similar adverse effect profiles. Keywords:Olopatadine, Levocetirizine, Allergic Rhinitis
Authors and Affiliations
Sridhar Rao Boyinapelly, Basani Ramesh Chandra
Keywords
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