A comparative study of efficacy of 0.5% timolol maleate versus 1% brinzolamide in case of primary open angle glaucoma and ocular hypertension
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 3
Abstract
Background: Glaucoma is the second largest cause of bilateral blindness in the world, after cataracts. In India, glaucoma accounts for 5.8% cases of blindness. Medical treatment is the first therapeutic approach for the treatment of glaucoma to lower raised IOP. Though the number of drugs have been used over years, an ideal agent has not yet been found. The present study was undertaken to compare the efficacy of 0.5% timolol maleate versus 1% brinzolamide in case of primary open angle glaucoma and ocular hypertension. Material and Methods: This was a prospective, randomized comparative study conducted on 50 patients of POAG or ocular hypertension. Patients were randomized into two equal groups as Group A and B. Group A received 0.5% timolol maleate and Group B received 1% brinzolamide. Patients were followed on day 0, week 4, week 8 and week 12for IOP measurements. Results: The baseline IOP readings taken at Day 0 were 24.63 ± 0.82 and 24.80 ± 1.06 for Group A and B respectively. When IOP readings were compared between the two groups, it was observed that across all visits during the 12 weeks treatment period IOP lowering produced with timolol maleate 0.5% was more as compared to brinzolamide 1%. Discussion: Treatment with timolol 0.5% was more effective in lowering the raised IOP than brinzolamide 1%.
Authors and Affiliations
Mahesh Chandra Agrawal, Neha Jain, Swati Tomar
Keywords
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