A COMPARATIVE STUDY OF EFFICACY OF HAND FOOT PSORALEN-ULTRAVIOLET A THERAPY VERSUS SEQUENTIAL THERAPY OF TOPICAL CLOBETASOL PROPIONATE WITH TOPICAL CALCIPOTRIOL OINTMENT IN PALMOPLANTAR PSORIASIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 45
Abstract
BACKGROUND Palmoplantar psoriasis that accounts for 3% - 4% of all psoriasis cases produces significant functional and social disability. Reduction of pain and improvement in the function of limbs are more important therapeutic goals than complete clearance. This prospective, randomised, controlled study was conducted in Coimbatore Medical College, a tertiary care centre in Tamilnadu. We conducted the study on 50 patients from September 2011 to November 2012. Aims and Objectives- The aims and objectives of the study was to compare the efficacy, to observe the reduction in percentage of psoriasis area and severity index score (PASI SCORE) above 50% and to observe the adverse effects in first 6 months and duration of remission in the next 6 months. MATERIALS AND METHODS We divided all patients into two groups- Who had taken phototherapy was Group A and Who had taken sequential therapy was Group B. SPSS (Statistical Package for Social Sciences) Ver. 20 was used to perform statistical analysis. T-test for equality of means was conducted to compare the two groups. RESULTS In Group A 81.8% of the patients and in Group B 91.6% of the patients showed more than 50% reduction of PASI score. The initial PASI score and percentage reduction was compared with 8th week score, 16th week and 24th week of treatment of both groups. The ‘t’ test result of percentage reduction showed significant difference at the end of 8th week (‘t’ value 2.618, P < 0.01), 16th week (‘t’ value= 3.288, P < 0.05), and 24th week (‘t’ value= 3.324, P < 0.05). CONCLUSION Efficacy of sequential manner is better than topical PUVA. Patients on PUVA therapy group developed more adverse effects and the duration of remission maintenance was short
Authors and Affiliations
Abirami Punniyaseelan, Revathy Mathan
Keywords
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- EP ID EP216832
- DOI 10.14260/Jemds/2017/761
- Views 89
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