A Comparative Study Of Etomidate And Midazolam Induction In Patients Undergoing Coronary Artery Bypass Graft Surgery
Journal Title: International Journal of Medical and Health Sciences - Year 2017, Vol 6, Issue 4
Abstract
Background :To compare the effects of etomidate and midazolam induction on hemodynamic changes during laryngoscopy and intubation in patients undergoing elective Coronary Artery Bypass Graft (CABG) surgery. Method and Material : A total of 70 patients with triple vessel coronary artery disease, aged between 30 to 60 years undergoing CABG surgery were included in this prospective, comparative and randomized study and divided into two groups; group E (Etomidate group, n=35, 0.3mg/kg) and group M (Midazolam group, n=35, 0.15mg/kg). Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central venous pressure (CVP), cardiac output (CO), cardiac index (CI) and systemic vascular resistance index (SVRI) were recorded at various time points starting from preinduction till 10 minutes after intubation. Statistical Analysis: The SPSS, version 20 for Windows statistical software package (SPSS inc., Chicago, Illinois, USA). Results were analyzed using student’s t-test and paired t-test. Results: In group M after induction HR increased (P <0.05); SBP and MAP decreased (P <0.05), while at 1 min after tracheal intubation the values of HR increased and SBP decreased (p <0.05). Whereas in group E, HR and SBP increased remarkably at 1 min after intubation (P < 0.001 and P <0.05, respectively). Both the groups showed no significant change in DBP, CO and CI before and after intubation. There was significant decrease in CVP in both the groups (P <0.001). Group M showed significant decrease in SVRI (P <0.001). Conclusion :In comparison with Etomidate, Midazolam used for the induction of anesthesia in CABG surgery was more effective in preventing the adverse cardiovascular response to laryngoscopy and intubation.
Authors and Affiliations
Bordi Pancholi, Reema Meena
Keywords
Related Articles
- EP ID EP40033
- DOI -
- Views 297
- Downloads 0
The Magnitude of Obesity and its relationship to Blood Pressure among Punjabi Residents of Delhi
Background: Body mass index (BMI) is an important tool for assessing nutritional status. Increased cases of obesity, hypertension and cardiovascular diseases particularly among adults in developing countries, requires d...
Malignant transformation in sebaceous cyst- A case report
Sebaceous cysts are among the most frequent skin lesions that are removed in an outpatient clinic. We encountered a case of malignant transformation in a long-standing sebaceous cyst of the scalp in 65 year old male. C...
Treatment Outcome of Tuberculosis in Seropositive Patients in a Tertiary Care Hospital and ART Centre in Mumbai, India
Background: Tuberculosis is one of the major health problems in India. The Tuberculosis problem is further aggravated by TB- HIV co-infection. TB is not only leading cause of death in HIV infected persons but it also a...
Patient with congenital aortic stenosis undergoing noncardiac surgery: Anaesthetic implication
Patients of congenital aortic stenosis requiring noncardiac surgery need special anaesthetic considerations as pathophysiology of aortic stenosis is complex & there occur significant effect of anaesthetic drugs on heart...
Etiology of Hemoptysis in India Revisited
Aims and Objectives: To study the changing trend in the causes of hemoptysis in India. Materials and Methods: Total of 246 patients complaining of hemoptysis were taken up for this prospective study. The study was appro...