A comparative study of haemodynamic effects of propofol and etomidate used as induction agent in general anaesthesia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Many anaesthetic drugs have been used as induction agent. Propofol, although most commonly used induction agent, causes significant reduction in arterial pressure. Another agent, etomidate, has advantage of minimizing hypotension. Materials and Methods: A total of fifty patients posted for surgery under general anaesthesia were taken up for the study and were randomly allocated into two groups. All patients received intravenous fentanyl citrate (2g/kg) followed by a study drug over 30-60 seconds. Propofol group (Gr P) received 2.5 mg/kg dose of propofol, and etomidate group (Gr E) received etomidate at 0.2 mg/kg. Heart Rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and SpO2 were noted at the following time intervals: before induction, at the end of induction (loss of eyelash reflex), at the end of intubation and after 5 minutes of intubation. Adverse effects such as pain on injection and myoclonus were also recorded. Results: Mean heart rate, SBP, DBP, and MAP recorded at different time intervals were lowest in Gr P. Pain on injection was significantly increased in Gr P (56%). Myoclonus was seen in Gr E (12%). Conclusion: Induction with 0.2 mg/kg of etomidate is better for its hemodynamic stability over propofol (2.5 mg/kg) along with less incidence of pain on injection. Only drawback was incidence of myoclonus.
Authors and Affiliations
Subrat Kumar Nayak, Khullem Maniram Singh2, Langpoklakpam Chaoba Singh, N Ratan Singh4, Dilip Ingudum5
Keywords
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- EP ID EP365260
- DOI 10.9790/0853-1702150106
- Views 92
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