A Comparative Study of Low Doses of Intrathecal Ketamine and Midazolam with Bupivacaine for Infraumbilical Surgeries
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 6
Abstract
Aim: The aim of this study is to evaluate the effect of the low doses of ketamine and midazolam with bupivacaine intrathecally in terms of duration of analgesia and haemodynamic parameters. Materials and Methods: This prospective randomized double blind study conducted in patients posted for Infra umbilical surgeries. Patients with physical status ASA I and ASA II with Infra umbilical surgeries like herniorrhaphy, varicose vein surgery, orthopaedic surgeries with less than 3 hr duration were taken up for the study. Results: All demographic details are not significant. With addition of midazolam and ketamine the mean onset of sensory block is quicker compared to other two groups. with addition of midazolam and ketamine the mean onset of motor block is quicker compared to other two groups. With addition of Midazolam and ketamine the maximum sensory level and reached in higher compared to other two groups. With addition of midazolam and ketamine the duration of sensory block and motor block is prolonged compared to other two groups. With addition of ketamine and Midazolam the mean duration of pain free interval is prolonged and rescue analgesics required are less compared to other two groups. In all three groups the mean systolic blood pressure was comparable and they are not statistically significant. The Vasopressors required in Group A and C were compared and they are not statistically significant. In Group B and Group C the sedation score was higher compared to Group A. Conclusion: Low doses of preservative free ketamine (0.1mg/kg) and midazolam (0.02mg/kg) when added to bupivacaine intrathecally provides prolonged post operative analgesia without any significant side effects.
Authors and Affiliations
C. Karpagavalli
Keywords
Related Articles
- EP ID EP541497
- DOI 10.21088/ijaa.2349.8471.5618.26
- Views 90
- Downloads 0
Comparison of Buprenorphine Versus Fentanyl as an Adjuvant to Bupivacaine in Supraclavicular Brachial Plexus Block
Adjuncts to local anesthetics for brachial plexus blockmay enhance the quality and duration of analgesia. Buprenorphine and Fentanyl both are opioids, known to produce antinociception and enhance the effect of local anes...
Intrathecal Nalbuphine versus Intrathecal Dexmedetomidine for Postoperative Analgesia of Lower Abdominal and Lower Limb Surgeries
ntroduction: Opioids are used as adjuncts with the local anaesthetic for longer duration of action and better postoperative analgesia [4]. Nalbuphine, is a mixed agonist-antagoniste and its analgesic potency is equal to...
A Comparative Study of Plain and Hyperbaric Solutions of Bupivacaine HCl During Spinal Anaesthesia
Background: Spinal anesthesia is often used for both elective and emergency surgeries. Anesthesia-related mortality is decreased when general anesthesia is avoided. Aim: To compare the anaesthetic behaviour and haemodyna...
Effect of Dexmedetomidine on Haemodynamic Response to Pneumoperitoneum in Patients Undergoing Laparoscopic Cholecystectomy
Background: As laparoscopic cholecystectomy is a routinely performed surgery, it is desirable to have a stable intraoperative haemodynamic status. This study is designed to evaluate the efficacy of single intravenous bol...
I Gel Versus Endotracheal Tube for Pediatric day Care Surgeries
Background: The I-gel TM (Intersurgical, Wokingham, UK) is a novel second generation supraglottic airway device with a non inflatable cuff, made up of a unique soft gel like material (Styrene Ethylene Butadiene Styrene)....