A Comparative Study of Preincisional Infiltration of Levobupivacaine 0.2% and Ropivacaine 0.375% for Postoperative Analgesia after Abdominal Surgery under General Anesthesia
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Introduction: Pre-emptive analgesia is defined as administration before surgical incision that prevent the development of central sensitization of incisional injury or inflammatory injuries (i.e. intraoperative and postoperative period). The aim of our study was to compare the analgesic potency of preincisional tissue infiltration with ropivacaine and levobupivacine in treating pain after abdominal surgeries. Materials and Methods: The present observational study was conducted among 90 patients posted for major abdominal surgery under general anaesthesia. Patients were randomly allocated into three groups of 30 patients each to compare the duration of postoperative analgesia with preincisional infiltration of levobupivacaine 0.2%, ropivacaine 0.375% and placebo in patients undergoing abdominal surgeries under general anaesthesia. Preincisional surgical field infiltration was done with study drug 20 ml of levobupivacaine, ropivacaine or normal saline by the operating surgeon after tracheal intubation. Statistical analysis was performed with the SPSS- 23. Groups were compared for quantitative data, presented as mean, standard deviation and by using students t-test. Probability P value <0.05 was considered statistically significant. Results: The study demonstrated that preemptive analgesia given by preincisional infiltration with both the study drugs, has a significant and beneficial effect on postoperative pain in the first 24 hours following in abdominal surgeries. In the present study, 16.66% of patients who received levobupivacaine, and 6 % of patients who received ropivacaine required rescue analgesic tramadol in 8 hours-12 hours interval and 13.33% patients of group L and 6.66% patients of group R required rescue analgesia in 12 hours – 24 hours interval in postoperative period. 6.66% of patients in groups L and 3.33% of patients in group R required rescue analgesic at 24 hours in postoperative period. But 73.33% patients of group C require rescue analgesic at 20-30 min interval and 26.66% patients of this group require analgesic dose at 30min- 60 min interval. Conclusion: Tissue infiltration with ropivacaine 0.375% or levobupivacaine 0.2% appears similarly effective in reducing the postoperative pain associated with abdominal surgeries under general anesthesia compared to patients receiving normal saline.
Authors and Affiliations
Narendra Singh Deval, Durga Jethava, Sudhir Sachdev, D. D. Jethava
Keywords
Related Articles
- EP ID EP531175
- DOI 10.21276/ijmrp.2018.4.1.126
- Views 91
- Downloads 0
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