A Comparative Study of the Diagnostic and Prognostic Value of Squamous Cell Carcinoma Antigen and Alfa-foeto Protien in Hepatocellular Carcinoma Before and After Therapeutic Intervention
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 11
Abstract
<strong>Background: </strong>hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and it is one of the major causes of death, because of its high frequency and poor prognosis. Hepatocellular carcinoma is now a common malignancy in Egypt which usually develops on top of liver cirrhosis secondary to viral infection, as hepatitis C viruses increased the risk of HCC in the Egyptian patients. <strong>Aim of the Work: </strong>was to verify the possibility of using the plasma squamous cell carcinoma antigen level as a tumor marker for hepatocellular carcinoma and to evaluate its prognostic value in management of HCC.<strong> Patients and Methods: </strong>the study included 60 subjects divided into three groups: group I was 30 patients with hepatocellular carcinomas, group II was 15 patients with liver cirrhosis and group III was 15 normal subjects serving as a control group.<strong> Results: </strong>the plasma SCCA level was significantly higher in group I patients (with HCC), than in the group II patients (cirrhosis) and control group. SCCA showed direct significant correlation with the most of laboratory data specially AST, INR, number and size of lesion.<strong> Conclusion: </strong>plasma SCCA is a sensitive and specific serum marker for the diagnosis of HCC and combination of AFP and SCCA in screening and diagnosis of HCC yielded a better sensitivity in diagnosis of HCC.
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584384
- DOI 10.12816/ejhm.2018.11542
- Views 115
- Downloads 0
Pediatrics Iron deficiency anemia from diagnosis to treatment
Aim: the significant points in diagnosis and treatment of iron deficiency which is one of the most common diseases observed in children have been compiled in terms of directing pediatricians, the recent studies performed...
Epidemiology, Bacteriology and Risk Factors of Surgical Wound Infections: A Systematic Review
<strong>Introduction:</strong> Surgical wound infections are a main cause of hospital associated infections in low income and the second most common cause in high income and resource rich countries. This review aiming at...
Diagnostic Procedures among Patients Undergoing Appendectomy: Findings from A Tertiary Hospital In Saudi Arabia
<strong>Objective: </strong>Acute appendicitis is a common surgical emergency. But often arriving at correct diagnosis is challenging. CT scan has reduced the rates of negative appendectomies but it has radiation risk. W...
The Influence of Acesulfame-K and Aspartame on Some Physiological Parameters in Male Albino Rats
Background: the easiest method of reducing calories is to replace the high caloric food products with sweetened ones. Aim of the work: this study aimed to determine the effects of acesulfame-k or aspartame on some physio...
Low-Molecular–Weight Heparin versus Unfractionated Heparin in Pregnant Women with Recurrent Abortion associated with Antiphospholipid Syndrome
Objectives: to compare the efficacy and safety of the combination of unfractionated heparin )UFH( and Low Dose Aspirin (LDA) with that of low-molecular-weight heparin )LMWH( and LDA in the management of pregnant women wi...