A Comparison of Intrathecal Neostigmine and Clonidine for Post-operative Analgesia in Total Abdominal Hysterectomies
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 2
Abstract
Background: Intrathecal neostigmine 5 μg and clonidine 30 μg with bupivacaine produce substantial antinociception and potentiate analgesia of bupivacaine. Aims: The aim was to investigate the effect of intrathecal neostigmine and clonidine on post-operative analgesia and hemodynamic when added to 0.5% hyperbaric bupivacaine. Subjects and Methods: In this prospective, randomized, and double-blind study, we took 90 patients of ASA Grade I and II adult female patients posted for total abdominal hysterectomies.patients were assigned into three groups of 30 patients each. Patients of Group 1 received neostigmine 5 μg, Group 2 received clonidine 30 μg, and Group 3 received normal saline as an adjuvant to 3 ml of hyperbaric bupivacaine. Onset, duration of analgesia, heart rate, mean arterial pressure, and adverse effects were recorded. Recorded data were statistically analyzed. P < 0.05 was statistically significant. Results: The mean duration of analgesia was significantly longer in Group 2 followed by Group 1 and lowest in Group 3. Additional analgesic requirement was significantly less in Group 2 followed by Group 1 and Group 3. The pain score was significantly less in Group 2. The incidence of hypotension and bradycardia was the lowest in Group 1. Conclusion: Neostigmine and clonidine both provide longer post-operative analgesia and neostigmine also provides better hemodynamic stability with fewer side effects.
Authors and Affiliations
Manjulata Shakya, Hansraj Baghel, Avtar Singh Yadav
Keywords
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