A Comparison Study for Chances of Reduction in Cardiovascular Risk by Draksharishta in Induced Diabetic Condition
Journal Title: Drug Designing & Intellectual Properties International Journal - Year 2018, Vol 1, Issue 3
Abstract
In this study was to evaluate the effect of Draksharishta-T and Draksharishta -M prepared by traditional and modern methods respectively and Dabur Draksharishta and comparison between them on fasting blood glucose and serum lipid profile in alloxan induced diabetic rats. Oral administration of Draksharishta-T, Draksharishta-M and Dabur Draksharishta (2ml/kg p.o.) for 21 days caused a significant decrease in fasting blood glucose (FBG) and showed significant rise in blood glutathione level (GSH) in diabetic rats. Glibenclamide was used as a standard anti diabetic drug (10 mg/kg, p.o). These preparations also caused significant reduction in serum cholesterol, LDL and triglycerides and showed significant rise in serum HDL level in diabetic albino rats. Thus all these preparations were able to maintain the tested parameters near to the normal level significantly. Now-a-days Diabetics is a major problem of our society, not only India most of the countries because of our life style. Diabetics have accelerated levels of oxidative stress and this contributes massively to most cardiovascular, neurological, retinal and renal diabetic complications [1]. Diabetes mellitus is a heterogeneous metabolic disorder as old as mankind and its incidence is considered to be high all over the world [2]. It is characterized by hyperglycemia. Hyperglycemia significantly diminishes glutathione levels lowering defenses against oxidative stress [3]. A multitude of herbs, spices and other plant material has been described for the treatment of diabetes throughout the world [4]. Furthermore, after the recommendations made by WHO (World Health Organization) on diabetes mellitus, investigations on hypoglycemic agents from medicinal plants have become more important. The levels of serum lipids are usually elevated in diabetes mellitus and such an elevation represents the risk factor for coronary heart disease. Moreover, diabetic patients experience a two to three fold increase in cardiovascular morbidity and mortality in comparison to non diabetics [5]. Draksharishta is a poly herbal hydro alcoholic preparation and is used as blood purifier, in the treatment of anemia and advised as a choice of remedy in respiratory problems. The chief ingredient of Draksharishta is draksha, dried fruits of Vitis vinifera [6].The composition and properties of fruits of Vitis vinifera, have been extensively investigated and it was reported that they contain large amount of phenolic compounds as catechins, epicatechin, quercetin, and gallic acid, dimeric, trimeric and tetrameric procyanidins [7]. These compounds have many favorable effects on human health such as lowering of human low density lipoproteins, reduction of heart disease and cancer [8- 11]. Therefore we undertook the present investigation to evaluate the anti diabetic effect of Draksharishta-T and Draksharishta-M prepared by traditional and modern methods respectively and also Dabur Draksharishta in alloxan induced hyperglycemic rats. Effect of these preparations was also evaluated on the serum lipid profile of alloxan induced diabetic rats.
Authors and Affiliations
Subhajit Ghosh, PN Murthy, H Joshi
Keywords
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- EP ID EP585945
- DOI 10.32474/DDIPIJ.2018.01.000111
- Views 221
- Downloads 0
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