A comprehensive review of therapeutic agents used in the treatment of recurrent aphthous ulcer and oral ulcers in Bechet’s syndrome
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 2
Abstract
Introduction Recurrent aphthous ulcer RAU is a common oral disease characterized by ulcers with an erythematous halo affecting 525 of the general population The underlying etiology is not clear but several factors are believed to be responsible for the pathogenesis of the disease including stress hormones genetic factors etc Behcet39ssyndrome is a multisystem disorder involving vasculitis of small and mediumsized vessels and inflammation of the epithelium characterized by recurring oral and genital ulcers with eye lesionsAimThe objectives of this paper were to compare different treatment options available for the patients suffering from RAU and major refractory oral aphthae without any systemic disease or any syndromes except Bechets associated with RAU published in the review of RAU point out drugs and therapies along with their dosages that may be used in the first line of treatment topical and second line of treatment systemicMaterials and Methods Pub Med search full text and abstracts with drugs belonging to several categories like anesthetics antibiotics and antiseptics corticosteroids antiinflammatory and antiallergic drugs hemorrheologic agents zinc substitutes immunomodulatory agents and chemical cauterizing agents was done Pub Med search term Behcet39s trial oral was used and only those publications that described clinical trial with drugs on patients with Behcets disease involving oral lesions were selectedResultTotal 62 articles were analyzed to extract the data regarding different therapeutic agents used in the treatment of Recurrent aphthous ulcer and oral ulcers in Bechets syndrome The drugs most commonly used were lidocaine benzocaine tetracycline chlorehexidine amlexenox and dexamethasone topically and prednisolone levamisole and thalidomide systemically as a single therapy or in combination The impact of immunomodulators and LASER in comparison with topical drugs also was assessed ConclusionNovel research strategies should be designed to clinically test combination therapies in the treatment of aphthous ulcersKeywords RAU aphthous ulcers Bechets syndrome
Authors and Affiliations
Sheshaprasad R. , Anuradha Pai
Keywords
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- EP ID EP478541
- DOI 10.18231/2393-9087.2018.0012
- Views 105
- Downloads 0
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