A correlation of plasma malondialdehyde, whole blood glutathione peroxidase and lipid profile in pulmonary tuberculosis
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 2
Abstract
Background: Tuberculosis is one of the commonest chronic infectious diseases; highly endemic in India, kills five lakh patients every year. Oxidative Stress plays important role in inflammatory & degenerative diseases including pulmonary tuberculosis. There is hardly any one study available in literature correlating oxidative stress, lipid profile values and antioxidant status together with the pulmonary tuberculosis; so we decided to conduct this study. Methods: Study group included newly diagnosed 100 cases of pulmonary tuberculosis and control group included 100, age and sex matched healthy volunteers and employees. All the subjects were subjected to complete physical and systemic examinations, routine investigations including Sputum for AFB by Ziehl-Neelsen staining, AFB culture and Chest x-ray and special tests like fasting lipid profile, plasma malondialdehyde, whole blood glutathione peroxidase and findings recorded and statistically analysed. Results: In the study group with 66 males and 34 females, we found total cholesterol mean ± SD 149.16±19.02; Triglycerides 114.36±13.38; HDL-C 36.61±4.17; LDL-C 92.78±13.72; VLDL-C 20.04±2.97; MDA 6.03±1.62 and GPx 6192.9±790.75 while in controls with 61 males and 39 females, these values were 183.51±14.63; 134.52±8.48; 43.46±4.65; 111.98±12.62; 28.95±4.95; 1.79±0.50 and 7739.27±429.80 respectively. Conclusion: Tuberculosis effect more males (66%) than females (34%). TC, TG, HDL-C, LDL-C, VLDL-C and GPx were found statistically significantly lower in study group when compared with control, (p <0.001) while MDA was found significantly higher in study group when compared with control, (p <0.001).
Authors and Affiliations
Anchit Bharat, Bharat Kumar Gupta, Jaskiran Kaur, Naresh Kumar, Vinay Bharat
Keywords
Related Articles
- EP ID EP242555
- DOI -
- Views 78
- Downloads 0
Study of emergency laboratory parameters in acute oraganophosphorus poisoning in a rural population- retrospective study
Introduction Organophosphorus poisoning OPP is one of the common medical emergencies among rural population in India due to suicide attempts The purpose of this study was to investigate the relationship between the initi...
A study to assess the iron status of regular blood donors
Blood transfusions save lives and improve health. The general impact of blood donation on iron status has been studied since the late 1970’s. Iron deficiency anemia is a common finding in regular blood donors. According...
Assessment of Lipoprotein (a) and Lipid Profile Pattern in patients of Pre-Eclampsia
Introduction: Preeclampsia is a hypertensive disorder of pregnancy characterized by endothelial dysfunction. The present study was planned to assess and compare the levels of serum Lipoprotein (a) and lipid profile in pr...
Mathematical model of evaluation of Insulin Resistance using Homeostasis Model Assessment – Insulin Resistance Index in patients with Hyperthyroidism
Aim: To evaluate insulin resistance using HOMA-IR index in patients with overt and subclinical hyperthyroidism. Materials and Method: A randomized case control study on female population was conducted. For which 30 overt...
Correlation of lipid profile with tobacco use in cataract patients
Introduction: Human beings are blessed with five special senses and vision is the most precious. Cataract is the major cause of a visual impairment. Tobacco use is a modifiable risk factor for cataract. Dyslipidemia is a...