A cross sectional study of correlation between HbA1c levels and lipid profile in type 2 diabetes mellitus patients
Journal Title: Medpulse International Journal of Medicine - Year 2018, Vol 7, Issue 1
Abstract
Background: The world is witnessing an epidemic of Diabetes, with rapidly increasing prevalence in both developing and developed countries. In developing countries like India, fast industrialization and modern lifestyle is causing more number of Diabetes patients daily. The number of Diabetes patients are likely to reach 80 million by the end of 2030. Diabetes mellitus is characterized by rise in blood sugar levels and subsequent lethal patho-physiological changes in all the body systems. It is classified into two types, type 1 and type 2. The type 2 diabetes is more prevalent and occurs either when the β-cells of pancreas do not produce enough insulin. Type 2 diabetes mellitus is often associated with abnormalities of lipoproteins which give rise to the increased incidence of micro vascular and macro vascular complications. Background: A cross sectional study was been carried out to evaluate the correlation of lipid profile and HbA1c levels. Method: We evaluated total 400 diabetic patients with type two DM visiting our department in a tertiary care hospital and medical college. HbA1c levels were used for classification of patients into good (< 7) and poor (≥ 7) glycaemic control and for comparing different lipid profile parameters in our study. Result: Majority (54.25%) of the patients were from the age group of 50 to 69 years. There was significant association between age and HbA1c levels (p= 0.026). Majority (56.50%) patients had the disease for more than 10 years, and there was significant association between the duration of diabetes and HbA1c levels (p= 0.046). Mean HbA1c level in study population was 8.61 ± 1.82, showing overall poor glycaemic control in study population, similarly the mean levels of lipids showed a deranged pattern in most of the patients. Very strong correlation was seen between FBS levels and HbA1c (p<0.0001). Positive correlation was seen between HbA1c levels and LDL and VLDL while negative correlation was seen between HbA1c and HDL levels. Conclusion: The study concludes that to maintain good lipid profile, better sugar control is required.
Authors and Affiliations
Sanjay Thorat, Tejas Rane, Aniket Avhad, Akshay Kulkarni
Keywords
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