A Double Blind, Randomized Comparison of Intubating Conditions between Rocuronium, Atracurium and Atracurium with Priming
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 4
Abstract
Background and Aims: The present study was undertaken to evaluate and compare rocuronium, with atracurium (with and without priming dose) for the purpose of intubation with emphasis on intubating conditions, haemodynamic changes and incidence of any adverse events. Methods: This prospective, comparative randomized study was conducted at Rajindra Hospital, Patiala, Punjab. A total of 150 patients aged between 18-60 years of either sex and ASA physical status I and II scheduled for elective surgery under general anaesthesia were randomly divided into three groups as follows: Group A (n=61): Rocuronium (0.6mg/kg), Group B (n=47): Atracurium (0.7 mg/kg), Group C (n=42): priming with 0.1 mg/kg prior to second dose of Atracurium 0.6 mg/kg. Intubating conditions and hemodynamic parameters were analyzed with one way ANOVA or Chi-Square Test or Fisher's Exact Test as applicable. Results: Rocuronium produced fastest onset of apnea (48.75 ± 8.91 seconds) and for the shortest period (29.82 ± 4.64 minutes). Atracurium without priming in comparison to Atracurium with priming had delayed onset of apnea (91.45 ± 28.89 seconds versus 73.31 ± 22.58 seconds) and longer duration of action (36.34 ± 12.77 minute versus 34.38 ± 10.34 minutes) respectively. (P value < 0.001) In group A, (Rocuronium), 100% patients had acceptable intubating condition at the end of 90 seconds. The hemodynamic parameters were comparable among three groups. Anaphylactic reactions were seen with atracurium usage both with and without priming. Conclusion: Rocuronium produces the better intubating conditions compared to Atracurium with or without priming at 90 seconds and is associated with shorter duration of action.
Authors and Affiliations
Parmod Kumar, Tripat Kaur Bindra, Smruti Rekha Hota
Keywords
Related Articles
- EP ID EP534245
- DOI 10.21276/ijmrp.2018.4.4.014
- Views 89
- Downloads 0
Compliance of Glaucoma Patients to Their Medical Treatment in Jeddah
Introduction: Glaucoma is an asymptomatic chronic eye disease in which timely treatment is important to prevent the potential irreversible blindness. Patient’s compliance with treatment is crucial for effective managemen...
Spinal Cord Arteriovenous Malformation: Presenting As Relapsing Paraplegia
Spinal arteriovenous malformations are rare cause of spinal cord syndromes. It is important in identifying them early as it is a potentially treatable cause. The clinical and radiological features may mimic demyelination...
A Comparative Study between Johnson Formula and Hadlock Formula For Estimating Fetal Weight in Term Gestation
Background: Ultrasound study forms a very important tool in present day obstetrics. Accurate assessment of weight by ultrasound examinations is mandatory for obstetric management particularly at term. Methods: A Prospect...
Obesity in Children and Its Connection to Diabetes in Saudi Arabia: Review
The significant rise in the rate and the prevalence of obesity in KSA in the past 20 years has increased high incidences of diabetes, as well as glucose intolerance levels. The research applied a cross-sectional study, a...
Knowledge and Attitudes Regarding Eye Donation and Corneal Transplants In Saudi Arabia: A Cross-Sectional Study
Background: Corneal transplantation is a method of choice for treating corneal blindness, a condition that leads to total vision loss. Saudi Arabia faces key challenges because a large number of people are waiting for co...