A facile synthesis and antibacterial screening of some new 4- Thiazolidinone derivatives
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 8
Abstract
Efficient syntheses of 4-thiazolidinone are affected by reaction of 6-methoxy-2-acetyl naphthalene and 4-methoxy-2-hydroxy benzaldehyde to give chalcone. This on further reaction with guanidine nitrite gives Amino Pyrimidine derivative. This amino Pyrimidine derivative treated with methyl chloroformate, hydrazine hydrate and various substituted aromatic aldehydes respectively yielded various Schiff bases. The reaction of various substituted Schiff bases with thioglycolic acid gives corresponding 4-thiozolidinone derivatives The various synthesized compounds were assigned on the bases of elemental analysis, IR and 1H NMR spectral data. The compounds are evaluated for their antibacterial activity.
Authors and Affiliations
Chirag K. Naik, Vikas A. Desai
Keywords
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- EP ID EP414382
- DOI 10.9790/5736-1108015559.
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