A Hospital Based Clinical Study on Patients with Colorectal Carcinoma Stage I
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 8
Abstract
Background: Colorectal carcinoma is a common surgical condition in India. The prognosis is good in Stage I but depends on the lymphovascular involvement which represents an important prognostic factor. Lymphovascular invasion is used as a criterion in assessing the aggressiveness of the carcinoma. Aim of the Study: The aim of the study was to study, identify high-risk factors in recurrences of Stage I colorectal carcinoma patients, using lymphovascular invasion as a working tool. Materials and Methods: A retrospective study on 43 patients undergoing curative surgery for colorectal carcinoma Stage I between 2008 and 2016 in a tertiary teaching hospital. The number of years with disease-free status is taken as an endpoint cure. Clinical and pathological factors which included lymphatic invasions were used to assess and analyze (univariate analyzes) the disease-free survival (DFS) period. Observations and Results: A total of 43 patients with Stage I colorectal carcinoma out of 138 patients (31.15%) with different stages of colorectal carcinoma were studied. Patients aged between 45 and 74 years were included with a mean age of 56.25 ± 3.60. Males were 32 and females were 11. The mean age in the females was 60.80 ± 2.70 and in males the mean age was 58.35 ± 2.40. The male to female ratio was 2.90:1. The univariate analysis showed that lymphovascular invasion was the only independent factor statistically significant and affecting the 5 years DFS. All the other factors such as age, gender, carcinoembryonic antigen values, lymph node involvement, tumor depth, and tumor location were not significant as the P value was above 0.05. Conclusions: In the present study, only the lymphovascular invasion was identified as an independent factor which was statistically significant in determining the 5 years DFS in patients with colorectal carcinoma Stage I undergoing curative resection. All the other factors were insignificant. The probable cause for the recurrence and metastases may be due to an undetected or undetectable local or systemic residual of the tumor at operation.
Authors and Affiliations
PG Ananda Kumar
Keywords
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