A Logarithmic Formula to Describe the Relationship between the Increased Radiosensitivity at Low Doses and the Survival at 2 Gray
Journal Title: Sultan Qaboos University Medical Journal - Year 2013, Vol 13, Issue 4
Abstract
Objectives: Intrinsic radiosensitivity at doses used in radiotherapy is linked to hypersensitivity (HRS) and increased radio resistance (IRR) at low doses. Te aim of this study was to explore this relationship. Methods: Survival curves for 18 human tumour cell lines were analysed, using two models to ft the data points in order to extract the necessary parameters relevant for this study. Results: Te IRR ratio α s /α r versus the survival at 2 gray (Gy) can be described by a logarithmic relation which leads to a series of straight lines. Conclusion: Te relationship obtained implies that there is a direct link between HRS/IRR and survival at clinically relevant doses of 2 Gy.
Authors and Affiliations
Faika A. Azooz| Department of Physics, College of Education, University of Mosul, Mosul, Ninevah, Iraq, Suzan K. Hashim| Department of Physics, College of Education, University of Mosul, Mosul, Ninevah, Iraq
Keywords
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