A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 2
Abstract
The online version of this article (doi:10.1208/s12248-012-9324-y) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Emilie Hénin, Martin Bergstrand, Joseph F. Standing, Mats O. Karlsson
The joint food and agriculture organization of the united nations/world health organization expert committee on food additives and its role in the evaluation of the safety of veterinary drug residues in foods
The Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) recommended the evaluation of food additives at the international level through the establishment of an expert com...
Theoretical Considerations and Practical Approaches to Address the Effect of Anti-drug Antibody (ADA) on Quantification of Biotherapeutics in Circulation
Continuous improvement in bioanalytical method development is desired in order to ensure the quality of the data and to better support pharmacokinetic (PK) and safety studies of biotherapeutics. One area that has been ge...
Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method
The objective of the present investigation was to study the antioxidant action of different flavonoids (quercetin, glabridin, red clover, and Isoflavin Beta, an isoflavones mixture) in order to determine if they could be...
Strategy to Prevent Drug-Related Hypersensitivity in Folate-Targeted Hapten Immunotherapy of Cancer
Cancer vaccine/immunotherapy rarely involves systemic administration of an immunogenic compound to an actively immunized host. We have developed such a strategy that utilizes folate to deliver antigenic haptens [e.g., fl...
Nonviral Gene Delivery: Principle, Limitations, and Recent Progress
Gene therapy is becoming a promising therapeutic modality for the treatment of genetic and acquired disorders. Nonviral approaches as alternative gene transfer vehicles to the popular viral vectors have received signific...