A Method for Highly Synthetic Benzofuran Ring
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2017, Vol 7, Issue 5
Abstract
Presently, a series of natural products – Houttuynoids – were isolated from Houttuynia, which exhibited promising anti-virus activity.1 As the amount of natural Houttuynoids from Houttuynia is rare, it is hard to separate and extract from Houttuynia. The synthesis of Houttuynoid B was completed based on the previous research.2 And, the benzofuran ring is a key intermediate for the synthesis of Houttuynoid B. However, the yield is low in his synthesis route. We have studied the synthesis of this benzofuran ring intermediate. Our route has greatly improved its synthetic yield. Their structures were characterized by 1H NMR, 13C NMR, ESI-MS and HRMS
Authors and Affiliations
Jilin Fan, Yiqun Chang, Jinsong Hou, Miaoqi Huang, Jingyuan Liu, Sijun Chen, Jialiang Guo, Pinghua Sun
Keywords
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- EP ID EP432693
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