A novel liquid oral formulation for 1- Octacosanol an anticancer drug and its stability study
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 3
Abstract
1-Octacosanol is a long chain fatty acid alcohol and a liphophilic waxy compound and hence by nature it is insoluble in water. Therefore, the respective drug active encounters a challenge of active absorption in the clinical settings. Thus, a necessity for the development of water soluble, a bio absorbable and a palatable formulation for 1- Octacosanol was addressed in this study. Apart from this, a secondary objective of presenting this drug product to pediatric and geriatric patients in a palatable manner, in order to increase their compliance. Various galenical feasibility studies were conducted to identify the specific ingredients and its respective proportion to bring out the desired emulsion. The resultant formulation facilitates the increased bioavailability; herewith we disclose a novel liquid oral emulsion formulation. It is a liquid oral emulsion dosage form of oil in water type, containing adjutants like Corn oil, Tween -80, Span-60, Sucralose, Flavour (raspberry), Water (DM), Simethicone, Methyl paraban, Propyl paraban etc. The final product exhibit a milky white emulsion, was further tested for its physical stability and its palatability through numerous experiments.
Authors and Affiliations
Shaji KP, Umesha S, Bharathi P Salimath
Keywords
Related Articles
- EP ID EP33318
- DOI -
- Views 278
- Downloads 0
ANTIFUNGAL ACTIVITY OF ETHANOLIC EXTRACT OF EUPATORIUM ADENOPHORUM LEAVES
The present study designed for phytochemical screening, anti fungal activity and physic chemical constants of ethanolic extracts of whole plant of Euphorbia thymifolia linn belongs to the family Euphorbiaceae, which is...
DIABETES EPIDEMIC IN INDIA: RISK FACTORS, SYMPTOMS AND TREATMENT
Diabetes is a metabolism disorder in which the pancreas in the human body fails to produce insulin, or is unable to use the insulin produced in an effective manner. Most of the food we eat is broken into glucose, which...
Structural properties of Zn1-xMnxO films
In recent years dilute magnetic semiconductors have paid much attention due to their complementary properties of semiconductors and ferromagnetic behavior. Zn1-xMnxO thin films have been prepared by chemical spray pyro...
Development and validation of RP-HPLC method for stability testing of Roxithromycin and Ambroxol hydrochloride
RP-HPLC method was developed for simultaneous estimation of Roxithromycin and Amroxol hydrochloride in pharmaceutical dosage forms. The method was validated for the simultaneous estimation of Roxithromycin and Ambroxol...
EVALUATION OF ANTI-ULCER EFFECTS OF ETHANOLIC EXTRACT OF DELONIX REGIA FLOWER
Ulcer is one of the most common disorder in the world. The available antiulcer drug in the market have different side effect. So the people move to herbal drug for a better result and lesser side effect. Delonix regia...