A novel treatment of severe dysmenorrhea due to adenomyosis: a case series of 3 infertile patients treated with dopamine agonist and in vitro fertilization-embryo transfer resulting in successful pregnancy
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 4
Abstract
Few therapies for adenomyosis are available for infertile patients with reduced ovarian reserve. Previous studies investigating dopamine agonists on endometriosis have reported a reduction of peritoneal endometriosis and nerve fiber density. The present authors hypothesized that this treatment could be applied to patients with adenomyosis. They describe three infertile patients who were treated with dopamine agonists for adenomyosis. All three patients had severe dysmenorrhea due to adenomyosis with a numerical rating scale (NRS) of 10. Patients were treated twice daily with 2.5 mg bromocriptine or twice weekly with 0.5 mg cabergoline for a duration ranging from four weeks to four months. After treatment, the NRS of dysmenorrhea was about 1~2 and all patients became pregnant via in vitro fertilization-embryo transfer. Dopamine agonist acts as neurotransmitter that binds to the D2 receptor on endothelial cells and promotes VEGFR-2 endocytosis, thereby reducing immature blood vessels, nerve fiber density, and resident macrophage of endometriosis.
Authors and Affiliations
H. Kwon, J. E. Shin
Keywords
Related Articles
- EP ID EP673420
- DOI 10.12891/ceog4580.2019
- Views 72
- Downloads 0
Brainstem injury in victims of sudden intrauterine death syndrome (SIUDS) and sudden infant death syndrome (SIDS)
Introduction: Sudden intrauterine death syndrome (SIUDS) and sudden infant death syndrome (SIDS) are often associated in a single pathology, resulting from an unexpected fetal or infant injury. Among the various causes,...
Adjusting progesterone (P) dosage to compensate for a non-homogeneous hyperechogenic (HH) echo pattern three days after embryo transfer
Purpose: To determine if in the modern era failing to attain a homogenous hyperechogenic (HH) pattern three days after embryo transfer is still associated with a lower pregnancy rates. The study evaluates the efficacy of...
Pregnancy outcomes vary with disease progression in pregnant women with schizophrenia
Purpose of investigation: It has been reported that pregnant women with schizophrenia have increased risk of adverse pregnancy outcomes. In this study, the authors aimed to investigate whether being admitted to the psych...
Diagnosis, evaluation, and delivery of primipara with twin reversed arterial perfusion (TRAP) syndrome
Тwin reversed arterial perfusion (TRAP) sequence is a rare complication in monochorionic twin pregnancy. It is the most serious type of transfusion syndrome (ТТТS). One twin has serious malformations, and due to the fact...
Accuracy of transvaginal ultrasound, saline infusion sonohysterography, and office hysteroscopy in the diagnosis of endometrial polyps
Background: Endometrial polyps (EPs) derive from overgrowths of stromal or endometrial glands supported by a fibrovascular core. Currently, there is no clear recommendation on the first-line tool to be employed between s...