A prospective randomized clinical trial for comparison of tramadol and dexmedetomidine for the control of intraoperative shivering under spinal anaesthesia
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 1
Abstract
Background and Aims: Pharmacological methods using variety of drugs like pethidine, morpine, tramadol, clonidine, doxapram, ketansarine, neofam, neostigmine, magnesium sulfate have been tried in post spinal shivering. In the hunt of more safe and efficacious drug, in our study, we compared two easily available and safe drugs dexmedetomidine and tramadol, intravenously administered for treating shivering in patients who received spinal anaesthesia for various surgical procedures. Methods: A prospective, randomised, study was conducted in 40 ASA I and II patients of either gender, aged between 20 and 60 years, scheduled for various surgical procedures under spinal anaesthesia. The patients were randomised in two groups of 20 patients each to receive either dexmedetomidine 1µg kg-1 or tramadol 1mg kg-1 as a slow intravenous bolus over 5 minutes. Grade of shivering, onset of shivering, time for control of shivering, recurrence and adverse effects were observed at scheduled intervals. Results: Time taken for cessation of shivering was 205.25±18.13 (sec) for dexmedetomidine and 413±16.92 (sec) for tramadol with (“p” value - 0.00). Nausea and vomiting was observed only in tramadol group. The sedation profile of both the drugs was comparable. Conclusion: Patients with post spinal anaesthesia shivering can be treated effectively by using dexmedetomidine (1 μg kg-1) and tramadol (1mg kg-1). Dexmedetomidine consumes less time for control of shivering compared to tramadol. It has advantage over tramadol due to reduced side effects like nausea and vomiting
Authors and Affiliations
Pavan Dhulkhed, Sunil V Khyadi
Keywords
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- EP ID EP589641
- DOI 10.26611/10151019
- Views 158
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