A Prospective Study of Safety and Efficacy of Thalidomide in Dermatology in a Tertiary care centre - Tamilnadu
Journal Title: Stanley Medical Journal - Year 2017, Vol 4, Issue 1
Abstract
Context: Thalidomide can be safely and effectively used in the treatment of Erythema Nodosum Leprosum(ENL), Pyoderma gangrenosum(PG),Discoid Lupus Erythematosus(DLE).Aims: The use of thalidomide in relation to dermatology is well- known. Enough data is available in the literature about various aspects of thalidomide. Our study aims to assess the safety and efficacy of Thalidomide in patients with ENL, PG, DLE and psoriasis who were refractory to conventional treatment.Settings and Design:The study was done in the Dermatology Department, Govt. Stanley medical college hospital using a prospective study design.Methods and Material: The study was an open label, prospective interventional study. The Study population included 20 patients each of ENL, Pyoderma gangrenosum, psoriasis and 10 DLE patients. Inclusion and Exclusion criteria were fulfilled.Statistical analysis used: nil Results: The response to thalidomide was excellent in 3 of the 4 conditions we studied. Our study implies that Thalidomide can be safely and effectively used in the treatment of ENL, Pyoderma gangrenosum, DLE, though the clinical response to treatment in Psoriasis is not much satisfactory.Conclusions:Thalidomide with its excellent tolerability can be used for many dermatological conditions as an alternative when other modalities are contraindicated or ineffective. Key Messages: Thalidomide is safe and effective
Authors and Affiliations
Senthil Kumar V, Afthab Jameela Wahab . , Anandan V, Sivaranjani J
Keywords
Related Articles
- EP ID EP217392
- DOI -
- Views 103
- Downloads 0
CONJUNCTIVAL CYSTIC PTERYGIUM
The halo sign is a circular area of groundglass attenuation that is seen around pulmonary nodules at computed tomography (CT). Although the sign is most often an indication of pulmonary hemorrhage, it may also accompany...
CLINICAL PROFILE, RISK FACTORS & OUTCOME OF PNEUMONIA IN 60 DAYS TO 60 MONTHS CHILDREN IN A TERTIARY CARE HOSPITAL
Background: Pneumonia is one of the leading causes of morbidity and mortality in the children. Hence, knowing the incidence, clinical profile of pneumonia in a tertiary care hospital will help in reduction of morbidity a...
COMPARISON STUDY BETWEEN OPEN TRANSINGUINAL PREPERITONEAL HERNIA REPAIR AND LICHENSTEIN’S HERNIA REPAIR
Context: The transinguinal pre peritoneal mesh repair is an amazing simplistic technique which gives an approach to inguinal, femoral and obturator hernias and bears the same anatomical relationship in TEP and TAPP appro...
ASSESSMENT OF THE AWARENESS LEVELS AMONG MOTHERS REGARDING INFANT FEEDING PR ACTICES IN THE RURAL FIELD PRACTICE AREA OF SIDDHARTHA MEDICAL COLLEGE, VIJAYAWADA
Context: In India about 1.9 million children die every year before they see their first birthday. During the weaning period, one out of four surviving children receives neither the quality nor the quantity of food need...
Isolated ovarian tuberculosis mimicking ovarian carcinoma
Although genitourinary tuberculosis is common, reports of isolated ovarian tuberculosis is rare. However, its presentation can mimick that of an ovarian tumour. A woman of 26 years presented with abdomen pain & distensio...