A RANDOMISED CONTROLLED STUDY TO EVALUATE THE EFFICACY OF ORAL MIDAZOLAM SYRUP AND INTRANASAL MIDAZOLAM SPRAY AS IDEAL PREMEDICANT IN CHILDREN UNDERGOING DIFFERENT TYPES OF SURGERIES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2014, Vol 1, Issue 6
Abstract
Most of the preschool children suffer from severe anxiety and apprehension before surgery. This can largely affect the smooth conductance and emergence from anaesthesia, with complications such as bronchospasm at the time of induction and emergence phenomenon at the end. This can lead to the development of maladaptive behavioral responses or posttraumatic stress disorders in later part of life. Midazolam in current time has emerged as an ideal premedicant having all the desirable properties in this regard. It has been used by several routes for premedication which includes oral and intranasal administration as most frequently used route. Each has its own advantage and disadvantage. The search for an ideal route and dose still exists. So the current study was planned to find out the efficacy of midazolam intranasally & orally. Midazolam is a benzodiazepine. It is highly lipid soluble invivo. Its lipid solubility is pH dependent, being more alkaline pH. It acts by binding to GABA-A receptors. It is metabolized by cyt P450 3A4. It has anxiolytic, amnesic, sedative, hypnotic, anticonvulsant & spinally mediated muscle relaxant property. Midazolam tastes bitter, so flavored midazolam syrup is available and its efficacy remains almost same and acceptability increases. The Midazolam nasal spray is also available.
Authors and Affiliations
Girish K. N. , Nikhil Anish
Keywords
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- EP ID EP221412
- DOI 10.18410/jebmh/2014/66
- Views 70
- Downloads 0
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