A randomised prospective study on the effect of intramuscular lignocaine and bupivacaine on induction dose of thiopentone sodium
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2017, Vol 4, Issue 3
Abstract
Introduction: The combination of regional and general anaesthesia is popular and there is growing interest in the possible interactions of the local anaesthetic agents(LA) with drugs used for general anaesthesia. The purpose of this study is to evaluate the hypnotic interaction between Thiopentone sodium with Lignocaine and Bupivacaine. Materials and Method: 90 ASA grade I and II patients of either sexes between the age groups of 18 to 50 years, scheduled to undergo various elective surgical procedures under general anaesthesia were included in the study. The patients were randomly allocated into three groups of 30 patients each. Group C received 3 ml of normal saline intramuscularly (i.m.) 10 minutes before induction, group L received lignocaine (2%) 2mg/kg body weight i.m 10 minutes before induction and group B received bupivacaine (0.5%) 1 mg/kg body weight i.m. 30 minutes before induction. General anesthesia was then induced with Thiopentone sodium till loss of eyelash reflex and the dose required was noted. The heart rate and blood pressure were noted for five minutes post induction. Results: The induction dose of thiopentone sodium in the group C was 4.64±0.35 mg/kg body weight (BW) it was significantly higher than the group L 3.65±0.30 mg/kg BW(p<0.001) and group B 3.23±0.22 mg/kg BW(p<0.001) The induction dose was reduced by 21% and 30% in the lignocaine and bupivacaine group respectively. Group L and B had a significantly attenuated response to intubation.
Authors and Affiliations
Vinayak Seenappa Pujari, Yatish Bevinaguddaiah
Keywords
Related Articles
- EP ID EP315200
- DOI 10.18231/2394-4994.2017.0075
- Views 96
- Downloads 0
Effect of addition of clonidine to bupivacaine or ropivacaine on caudal efficacy and effectiveness in pediatric patients undergoing infraumblical surgery
Introduction: Children are not as expressive as adults, but they do feels pain equally. In the perioperative period, pain is the most alarming, upsetting and disturbing symptom for a patient. In pediatric populace, among...
Comparative study of dexamethasone nebulisation with magnesium sulphate nebulisation in preventing post operative sore throat following endotracheal intubation
Introduction Postoperative sore throat is one of the most common complications following endotracheal intubation Though considered minor complication it may cause significant patient dissatisfaction Various nonpharmacolo...
Optimal dose of methylprednisolone for reduction of propofol injection pain: A randomized, double-blind, placebo controlled study
Introduction and Aims Propofol 26diisopropylphenol used for the induction of anaesthesia often causes mild to severe pain on injection for which various methods have been tried but with conflicting results We designed a...
Bispectral index monitoring during total intravenous anaesthesia: A comparative study between two dosage regimes of propofol
Introduction The potential longterm complication of intraoperative awareness needs to be addressed These complications range from mild auditory perceptions to being fully awake Studies with prospective patient interviews...
Intraoperative requirement of Phenylephrine for spinal anaesthesia, with comparison of hemodynamic parameters between severe pre-eclamptic and normotensive parturients for elective caesarean section: A prospective study
Aim: The aim of this study is to assess the efficacy and safety of spinal anaesthesia by comparing the severity of hypotension and intraoperative requirement of Phenylephrine to treat it in severe pre-eclamptic and normo...