A Randomized Clinical Trial to Compare the Efficacy of Dexmedetomedine and Magnesium Sulphate for Attenuation of Pressor Response in Abdominal Laproscopic Surgeries
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2019, Vol 6, Issue 3
Abstract
Objectives: To evaluate the response of dexmedetomidine and magnesium sulphate for attenuating stress response in laparoscopic abdominal surgeries. Material and methods: Patients of ASA grade I and II aged between 20 and 60 years, either gender and who underwent elective laparoscopic abdominal surgeries were included in the study and divided into two groups, group D (n=52) and group M (n=52). Group D patients received Inj dexmedetomidine 1 µg/kg bolus for 15 min followed by 0.2-0.4 µg/kg /hr infusion and group M patients received inj magnesium sulphate 2g bolus for 15 min followed by 12-15 mg/kg/hr infusion. Intraoperative hemodynamic parameters like Heart rate, mean arterial pressure were recorded and emergence time, extubation time and sedation scores were assessed. Results: Heart rate and Mean arterial pressure were significantly low in group D compared to group M. Recovery time and sedation score was significantly higher in group M compared to group D. Time to reach Aldrete score ≥ 9 was significantly more in group M compared to group D. Conclusion: Dexmedetomidine and Magnesium sulphate attenuated stress response to surgery and pneumoperitoneum. Dexmedetomidine had better hemodynamic stability compared to Magnesium sulphate. Early post operative recovery was found in dexmedetomidine group.
Authors and Affiliations
K. Nirmala Devi
Keywords
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- EP ID EP619650
- DOI 10.21088/ijaa.2349.8471.6319.8
- Views 90
- Downloads 0
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