A RANDOMIZED COMPARATIVE STUDY OF PHARMACOLOGICAL EFFECTS OF 1 % TROPICAMIDE WITH 10% PHENYLEPHRINE ON HUMAN EYES
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 4
Abstract
Aim and objectives: Comparison of the pharmacological effects like, pupillary diameter, intraocular tension, blood pressure, heart rate, of 1 % Tropicamide with 10 % Phenylephrine eye drops Methods: Present studies taken 60 individual patients, were divided into two groups: Group-1: 30 patients were in this group who received 1% Tropicamide eye drop, Group-2: 30 patients were in this group who received 10% Phenylephrine eye drop. After instillation of drugs on both eyes, pupillary diameter, intraocular tension, blood pressure and heart rate measured with using of various equipments and results were evaluated. Results: After 45 minutes 1% Tropicamide induced a marked mydriatic effect greater than that produced by 10% phenylephrine with no changes in refraction or visual acuity. IOT was significantly decreased only in normal patients after instillation of 1% tropicamide, whereas 10% phenylephrine shown no statistically significant changes. In the present study there was increased in Blood pressure and Heart rate in Phenylephrine group, when compared with Tropicamide group. Conclusion: In our study because of rapid onset, brief duration of mydriatic action, greater diffusibility of the drug into cornea, 1% Tropicamide was found to be a better mydriatic than 10% Phenylephrine. Adverse effect like, Blood pressure and heart rate were major drawbacks for Phenylephrine but the overall safety of Tropicamide was better in our study.
Authors and Affiliations
S. Manju Bhargavi| Department of Pharmacology, M.V.J Medical College and Hospital, Hoskote, Karnataka, India., B. Ramanath*| Department of Pharmacology, Basaveshwara Medical College, Hospital and Research Center, Chitradurga, Karnataka, India.
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