A Randomized, Controlled, Prospective Study To Compare The Efficacy And Safety of Zinc And Probiotics As Adjunct Therapy In Acute Diarrheal Disease of Children.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Aim: To compare the safety of zinc and probiotics as adjunct therapy in acute diarrheal disease in children of 6 to 24 months of age. Methods: Children of age 6 to 24 months with acute diarrheal disease admitted in the pediatric ward were randomized into 3 groups. Along with the usual fluid replacement therapy, first group received 20mg of zinc sulphate tablet once daily, the second group received probiotics saccharomyces 2.5 billion spores & lactic acid bacillus 100 million spores. The control group received only fluid replacement .Stool frequency and consistencies, mean duration of diarrhea, episodes of vomiting and amount of fluids utilized were monitored in the three groups. Results: Stool frequency and stool consistency improved faster in the zinc than the other groups and the probiotics group improved faster than the control. The mean duration of diarrhea was much shorter in the zinc group. The amount of ORS and IV fluids utilized was also much lower in the zinc group, but episodes of vomiting were more. Conclusion: This study supports the fact that zinc supplementation is effective and safe in the treatment of ADD as an adjunct to fluid replacement. Probiotics also play a role in reducing the severity of illness but only next to zinc.
Authors and Affiliations
Dr S. Pauline Packiaseeli, Dr Ezhil Ramya
Keywords
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- EP ID EP395371
- DOI 10.9790/0853-1709050108.
- Views 80
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