A Rare Case with Werner’s Syndrome was Developed Cirrhosis due to Steatohepatitis During of Follow-up Period
Journal Title: Scholars Journal of Medical Case Reports - Year 2015, Vol 3, Issue 4
Abstract
Abstract: Werner’s syndrome is a rare autosomal recessive, hereditary systemic disease with progeroid features, usually presenting in adolescence. Its clinical manifestations are short stature, scleroderma-like skin changes, cataracts, premature aging of the face, gray hair, genital hypoplasia and endocrinological abnormalities. Cirrhosis is an extremely rare manifestation of Werner's syndrome. It has been reported in <4% of patients. A 31-year old man, with Werner’s syndrome, he had been followed the last presention for liver failure were evalueted and cirrhosis was diagnosed due to steatohepatitis by liver biopsy. In 1999 initial diagnosis; cataracts, DM, short stature, and genital hypoplasia were found. In 2002 was showed steatohepatitis by liver biopsy which was performed for the persisting high liver transaminases. In 2007 developed gray hair, high-pitched voice, hypergonadotropic hypogonadism and osteopenia. He was a month ago had been hospitalised for nausea and vomiting with hematemesis. He was admitted to our hospital performed in the upper gastrointestinally endoscopy by the depertmant of gastroenterologia was found esophageal varices and to them was performed band ligation. Laboratory investigations and the imaging methods were showed as chronic liver disese. It was not found for other causes of chronic liver disease. In coclusion, here, we want to present a case with Werner’s syndrome who had cirrhosis due to steatohepatitis during of follow-up period in our clinic. Keywords: Werner’s syndrome, Steatohepatitis, Cirrhosis.
Authors and Affiliations
Mehtap Evran, Gamze Akkuş, Murat Sert, Tamer Tetiker, Arbil Avcı, Figen Doran
Keywords
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